Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2004-08-23
2009-11-24
Audet, Maury (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S001690, C530S330000, C530S331000
Reexamination Certificate
active
07622441
ABSTRACT:
The present invention provides methods for altering controlled substances in a manner that decreases their potential for abuse. The novel compounds may be combined in tablets with suitable excipients or formulated in solution for oral delivery. When delivered by the oral route the controlled substance is released in a time-dependent manner (sustained release) by acid hydrolysis and/or enzymatic cleavage. When administered by injection the controlled substance is released in a time-dependent manner (sustained release) by way of serum enzymes.
REFERENCES:
patent: 3843696 (1974-10-01), Wagner et al.
patent: 3846399 (1974-11-01), Hirschmann et al.
patent: 3878187 (1975-04-01), Schneider et al.
patent: 3884898 (1975-05-01), Schneider
patent: 3975342 (1976-08-01), Gross
patent: 3998799 (1976-12-01), Bodor et al.
patent: 4025501 (1977-05-01), Leute
patent: 4040907 (1977-08-01), Ullman et al.
patent: 4297346 (1981-10-01), Rips et al.
patent: 4356166 (1982-10-01), Peterson et al.
patent: 4399121 (1983-08-01), Albarella et al.
patent: 4427660 (1984-01-01), Schiffman et al.
patent: 4457907 (1984-07-01), Porter
patent: 4552864 (1985-11-01), Antoni et al.
patent: 4650675 (1987-03-01), Borel et al.
patent: 4801575 (1989-01-01), Pardridge
patent: 4863735 (1989-09-01), Kohn et al.
patent: 4902505 (1990-02-01), Pardridge et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 4976962 (1990-12-01), Bichon et al.
patent: 5026827 (1991-06-01), Miyazaki et al.
patent: 5073641 (1991-12-01), Bundgaard et al.
patent: 5087616 (1992-02-01), Myers et al.
patent: 5169933 (1992-12-01), Anderson et al.
patent: 5183883 (1993-02-01), Tanaka et al.
patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5238714 (1993-08-01), Wallace et al.
patent: 5362831 (1994-11-01), Mongelli et al.
patent: 5501987 (1996-03-01), Ordonez et al.
patent: 5529915 (1996-06-01), Phillips et al.
patent: 5534496 (1996-07-01), Lee et al.
patent: 5670477 (1997-09-01), Poduslo et al.
patent: 5762909 (1998-06-01), Uzgiris
patent: 5767227 (1998-06-01), Latham et al.
patent: 5846743 (1998-12-01), Janmey et al.
patent: 5851536 (1998-12-01), Yager et al.
patent: 5882645 (1999-03-01), Toth et al.
patent: 5891459 (1999-04-01), Cooke et al.
patent: 5898033 (1999-04-01), Swadesh et al.
patent: 5910569 (1999-06-01), Latham et al.
patent: 5948750 (1999-09-01), Garsky et al.
patent: 5952294 (1999-09-01), Lazo et al.
patent: 5977163 (1999-11-01), Li et al.
patent: 6005004 (1999-12-01), Katz et al.
patent: 6030941 (2000-02-01), Summerton et al.
patent: 6043230 (2000-03-01), Arimilli et al.
patent: 6048736 (2000-04-01), Kosak
patent: 6074659 (2000-06-01), Kunz et al.
patent: 6093391 (2000-07-01), Kabanov et al.
patent: 6235718 (2001-05-01), Balasubramanium et al.
patent: 6255285 (2001-07-01), Kotake
patent: 6306993 (2001-10-01), Rothbard et al.
patent: 6309633 (2001-10-01), Ekwuribe et al.
patent: 6458842 (2002-10-01), Dickinson et al.
patent: 6740641 (2004-05-01), Gao
patent: 6784186 (2004-08-01), Jackson
patent: 2001/0031873 (2001-10-01), Greenwald et al.
patent: 2002/0098999 (2002-07-01), Gallop et al.
patent: 2002/0099013 (2002-07-01), Piccariello et al.
patent: 2002/0151526 (2002-10-01), Gallop et al.
patent: 2002/0151529 (2002-10-01), Cundy et al.
patent: 2002/0164373 (2002-11-01), Maloney
patent: 2003/0077297 (2003-04-01), Chen et al.
patent: 2003/0091593 (2003-05-01), Bachmann et al.
patent: 2004/0204434 (2004-10-01), Shafer
patent: 54168/65 (1965-01-01), None
patent: 0 187 547 (1987-07-01), None
patent: 1421130 (1965-01-01), None
patent: 1092089 (1967-11-01), None
patent: 1112347 (1968-05-01), None
patent: WO 94/11021 (1994-05-01), None
patent: WO 95/12605 (1995-05-01), None
patent: WO 95/14033 (1995-05-01), None
patent: WO 97/36616 (1997-10-01), None
patent: WO 98/04277 (1998-02-01), None
patent: WO 00/37103 (2000-06-01), None
patent: WO 02/34237 (2002-05-01), None
Hughes, et al. Lipidic Peptides. II1: Lipidic Amino Acid and Oligomer Conjugates of Morphine, Journal of Pharmaceutical Sciences, vol. 80, No. 12, Dec. 1991 (cited in IDS of Oct. 23, 2007).
Supplementary European Search Report for EP 01273387 dated Sep. 28, 2004.
Thomson Derwent World Patents Index.
International Search Report for PCT/US03/05524 dated Feb. 24, 2003.
International Search Report for PCT/US03/05525 dated Oct. 9, 2003.
International Search Report for PCT/US04/17204 dated Oct. 15, 2004.
Aggarwal, et al., “Synthesis and Biological Evaluation of Prodrugs of Zidovudine,”J. Med. Chem., 33(5):1505-1511 (1990).
Amidon, G., et al., “A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability,”Pharmaceutical Research, vol. 12, No. 3 (1995).
Amidon, G.L., et al., “5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT are Absorbed by the Intestinal PEPT1 Peptide Transporter,”Pharm Res, 16(2):175 (1999), Abstract.
Balimane, P., et al., “Effect of Ionization on the Variable Uptake of Valacyclovir via the Human Intestinal Peptide Transporter (hPepT1) in CHP cells,”Biopharm Drug Dispos, 21(5):165-174 (2000), Abstract.
Balimane, P.V., et al., “Direct Evidence for Peptide Transporter (PepT1)-Mediated Uptake of a Nonpeptide Prodrug, Valacyclovir,”Biochem Biophys Res Commun, 250(2):246-251 (1998), Abstract.
Bunevicius, R., “Effects of Thyroxine as Compared with Thyroxine Plus Triiodothyronine in Patients with Hypothyroidism,”The New England Journal of Medicine, vol. 340, No. 6 (1999).
Burnette, Thimysta C., et al., “Metabolic Disposition of the Acyclovir Prodrug Valaciclovir in the Rat,”Drug Metabolism and Disposition, 22(1):60-64 (1994).
Canaris, G., “The Colorado Thyroid Disease Prevalence Study,” Archives Internal Medicine Articles and Abstracts, vol. 160, No. 4 (2000).
De Vrueh, Remco L.A., et al, “Transport of L-Valine-Acyclovir Via the Oligopeptide Transporter in the Human Intestinal Cell Line, Caco-2,”Journal of Pharmacology and Experimental Therapeutics, 286(2):1166-1170 (1988).
Friedrichsen, G.M., et al., “Model Prodrugs Designed for the Intestinal Peptide Transporter. A Synthetic Approach for Coupling of Hydroxy-Containing Compounds to Dipeptides,”Eur J Pharm Sci, 14(1):13-19 (2001, Abstract.
Guo, A., et al., “Interactions of a Nonpeptidic Drug, Valacyclovir, with the Human Intestinal Peptide Transporter (hPEPT1) Expressed in a Mammalian Cell Line,”Pharmacol Exp Ther, 289(1):448-454 (1999), Abstract.
Han H., et al., “5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT and Absorbed by the Intestinal PEPT1 Peptide Transporter,”Pharm Res, 15(8):1154-1159 (1998), Abstract.
Han, H.K., et al., “Cellular Uptake Mechanism of Amino Acid Ester prodrugs in Caco-2hPEPT1 Cells Overexpressing a Human Peptide Transporter,”Pharm Res, 15(9):1382-1386 (1998), Abstract.
Han, Hyo-Kyung, et al., “Targeted Prodrug Design to Optimize Drug Delivery,”AAPS PharmSci, 2(1): Article 6 (2000).
Havranova, Marie et al., “A High-Molecular Mass Derivative of Trypsin-Kallikrein Inhibitor for Potential Medical Use, II,”Hoppe-Seyler's Z. Physiol. Chem., 363:295-303 (1982).
Herrera-Ruiz, D., et al., “Spatial Expression Patterns of Peptide Transporters in the Human and Rat Gastrointestinal Tracts, Caco-2 in vitro Cell Culture Model, and Multiple Human Tissues,”AAPS PharmSci, 3(1):E9 (2001), Abstract.
Hosztafi, S. et al. “Synthesis and Analgetic Activity of Nicotinic Esters of Morphine Derivatives,” Arzneim.-Forsch./Drug Res. 43(II), Nr. 11 (1993).
International Search Report, dated Oct. 9, 2003, for PCT/US03/05525.
International Search Report, dated Sep. 3, 2003.
Knutter, I, et al., “A Novel Inhibitor of the Mammalian Peptide Transporter PEPT1,”Biochemistry, 40(14):4454-4458 (2001), Abstract.
Kovacs, J., et al., “Glutamic and Aspartic Anhydrides. Rearrangement of N-Carboxyglutamic 1,5-Anhydride to the Leuchs' Anhydride and Conversion o
Krishnan Suma
Lauderback Christopher
Mickle Travis
Moncrief James Scott
Piccariello Thomas
Audet Maury
Darby & Darby
Shire LLC
LandOfFree
Sustained release pharmaceutical compounds to prevent abuse... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained release pharmaceutical compounds to prevent abuse..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release pharmaceutical compounds to prevent abuse... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4127697