Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2006-03-15
2009-08-04
Richter, Johann R (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C514S494000, C514S497000, C514S499000, C514S505000, C424S401000
Reexamination Certificate
active
07569558
ABSTRACT:
The present invention relates to a method for topical delivery of trace metals for the modulation of certain metalloenzymes. The method of topical delivery of the present invention comprises; (i) mixing of a trace metal salt of a phosphorylated nitrogen heterocyclic base complexed with a chelating agent [Figure l], and (ii) a carrier, and (iii) topical application of said mixture. The modulation of metalloenzymes such as Superoxide Dismutase, Elastase, Tyrosinase, Matrix metalloproteases, and Ubiquitin-Proteasome pathway by the methods of the present invention is useful for providing anti-inflammatory, skin whitening, wrinkles reduction, skin aging control, cellular antioxidant, acne control, hair growth modulation, and skin damage control benefits.
REFERENCES:
patent: 1298069 (2002-09-01), None
patent: 2044265 (1980-10-01), None
Harris (Cellular copper transport and metabolism, annual review of nutrition, 2000, vol. 20 pp. 291-310).
Bioderm Research
Karpinski Luke E
Richter Johann R
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