Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-07-01
1996-09-17
Knode, Marian C.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352402, 435 2423, 435240243, 43524025, C12N 500, C12N 502
Patent
active
055567835
ABSTRACT:
A method of culturing hair follicular stem cells by isolating a subpopulation of follicular keratinocytes from the upper portion of a hair follicle, dispersing the isolated keratinocytes into a single cell suspension, and growing the dispersed isolated keratinocytes in the presence of 3T3 feeder cells is provided. A method of evaluating the efficacy of agents for modulating the activity of bulge cell populations by exposing bulge cells to an agent to be tested and comparing the response of the test cells to established controls for bulge cells is also provided. Methods of modulating the activity of hair follicular stem cells by identifying a subpopulation of follicular keratinocytes from the upper portion of a hair follicle and contracting the cells with a selected agent to stimulate growth or to selectively kill the cells is also provided.
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Lavker Robert M.
Sun Tung-Tien
Yang Jing-Shan
Dadio Susan M.
Knode Marian C.
New York Univ.
Trustees of Univ. of Penna
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