Method for detecting Branhamella catarrhalis

Details Method for detecting Branhamella catarrhalis Method for detecting Branhamella catarrhalis

1993-09-29

1996-09-17

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435871, 536 237, 536 2432, 536 2433, 536 253, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C12N 1500

Patent

active

055567550

ABSTRACT:
Compositions comprising outer membrane protein "CD", and peptides thereof, of Branhamella catarrhalis are described. Additionally, nucleotide sequences encoding the protein or peptide are disclosed, as well as recombinant vectors containing these sequences. Protein or peptide can be produced from host cell systems containing these recombinant vectors. Peptides can also be chemically synthesized. Disclosed are the uses of the protein and peptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding CD as primers and/or probes in molecular diagnostic assays for the detection of B. catarrhalis.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5030556 (1991-07-01), Beaulieu et al.
Bartos and Murphy, "Comparison of the Outer Membrane Proteins of 50 strains of Branhamella catarrhalis", Journal of Infectious Diseases, vol. 158, No. 4, 1988, pp. 761-765.
Sarwar et al., "Characterization of an Antigenically Conserved Heat-Modifiable Major Outer Membrane Protein of Branhamella catarrhalis", Infection and Immunity, vol. 60, No. 3, pp. 804-809.
Sequence comparison printout; Registry No. 129187-22-0.
Sommer and Tantz, Nucleic Acids Research, vol. 17, No. 16, 1989, p. 6749.

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