Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-03-24
1996-09-17
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435974, 435975, 530324, 530325, 530326, 530327, 530328, 530826, C12Q 170
Patent
active
055567444
ABSTRACT:
The present invention provides a panel of HIV peptides useful in diagnosing whether or not a patient is of vertical HIV transmission status, methods for diagnosing same, methods for identifying epitopes and peptides associated with non-transmission status, and pharmaceutical and vaccine compositions containing same.
REFERENCES:
Geysin et al, "Cognitive features of continuous antigenic determinants", J. Molecular Recognition, vol. 1 No. 1 (Feb. 1988) pp. 32-41.
LaRosa et al, Science, vol. 249, pp. 932-935, 24 Aug. 1990.
Warren et al, Journal of Virology, vol. 64(2) pp. 486-492 Feb. 1990.
K. Ugen et al, "Vertical Transmission of Human Immuno-deficiency Virus (HIV) Infection--Reactivity of Maternal Sera with Glycoprotein 120 and 41 Peptides from HIV Type 1", J. Clin. Invest., 89:1923-1930 (Jun. 1992) [Ugen I].
K. Ugen et al, "Vertical Transmission of HIV Infection: Maternal Humoral Immune Responses to gp120 and gp41 Peptides", Vaccines 92, pp. 183-189, Cold Spring Harbor Laboratory Press (Apr. 3, 1992) [Ugen II].
P-A. Broliden et al, "Diagnostic Implication of Specific Immunoglobulin G Patterns of Children Born to HIV-infected Mothers", AIDS, 3:577-582 (Sep. 1989) [Broliden I].
P-A. Broliden et al, "Identification of Human Neutralization-Inducing Regions of the Human Immuno-deficiency Virus Type 1 Envelope Glycoproteins", Proc. Natl. Acad. Sci. USA, 89(2):461-465 (Jan. 15, 1992) [Broliden II].
Y. Devash et al, "Vertical Transmission of Human Immuno-deficiency Virus is Correlated with the Absence of High-Affinity/Avidity Maternal Antibodies to the gp120 Principal Neutralizing Domain", Proc. Natl. Acad. Sci. USA, 87(9):3445-3449 (May 1990) [Devash I].
Y. Devash et al, "C-Terminal Fragments of gp120 and Synthetic Peptides from Five HTLV-III Strains: Prevalence of Antibodies to the HTLV-III-MN Isolate in Infected Individuals", AIDS Research and Human Retroviruses, 6(3):307-316 (Apr. 4, 1990) [Devash II].
P. Rossi et al, "Presence of Maternal Antibodies to Human Immunodeficiency Virus 1 Envelope Glycoprotein gp120 Epitopes Correlates with the Uninfected Status of Children Born to Seropositive Mothers", Proc. Natl. Acad. Sci. USA, 86:8055-8058 (Oct. 1989) [Rossi I].
J. Goedert et al, "Mother-to-Infant Transmission of Human Immunodeficiency Virus Type 1: Association with Prematurity or Low Anti-gp120", The Lancet, pp. 1351-1354 (Dec. 9, 1989).
P. Rossi, "Maternal Factors Involved in Mother-to-Child Transmission of HIV-1", J. Acq. Imm. Def. Syn., 5(10):1019-1029 (Nov. 1992) [Rossi II].
C. Robertson et al, "Maternal Antibodies to gp120 V3 Sequence do not Correlate with Protection Against Vertical Transmission of Human Immunodeficiency Virus", J. Infect. Dis., 166(4):704-709 (Oct. 1992).
S. Wolinsky et al, "Selective Transmission of Human Immunodeficiency Virus Type-1 Variants from Mothers to Infants", Science, 255:1041-1180 (Feb. 28, 1992).
J. Cotropia et al, "Characterization of Human Monoclonal Antibodies to the HIV-1 Transmembrane gp41 Protein", Vaccines92, pp. 157-163, Cold Spring Harbor Laboratory Press (Jul. 21, 1992).
D. McPhee et al, "Recognition of Envelope and tat Protein Synthetic Peptide Analogs by HIV Positive Sera or Plasma", FEBS Letter, 233(2):393-396 (Jun. 1988).
D. van Tijn et al, "Antigenicity of Linear B-Cell Epitopes in the C1, V1, and V3 Region of HIV-1 gp120", J. Acq. Imm. Def. Syn., 2(3):303-306 (Jun. 1989).
P. Tijssen, "Practice and Theory of Enzyme Immunoassays", Laboratory Techniques in Biochemistry and Molecular Biology, 15:9-21, 329-384 (Aug. 1985).
J. Krowka et al, "Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Glycoproteins Recognized by Antibodies in the Sera of HIV-1-Infected Individuals", Clin. Immunol. Immunopath., 59(1):53-64 (Apr. 1991).
K. Takahashi et al, "Specific Lysis of Human Immuno-deficiency Virus Type 1-Infected Cells by a HLA-A3.1-Restricted CD8+ Cytotoxic T-lymphocyte Clone that Recognizes a Conserved Peptide Sequence within the gp41 Subunit of the Envelope Protein", Proc. Natl. Acad. Sci. USA, 88(22):10277-10281 (Nov. 15, 1991).
S. Modrow et al, "Carrier-Bound Synthetic Peptides Use as Antigen in HIV-1 ELISA Tests and in Antiserum Production", J. Immunol. Meth., 118(1):1-7 (Mar. 1989).
J. Berzofsky et al, "Construction of Peptides Encompassing Multideterminant Clusters of Human Immunodeficiency Virus Envelope to Induce in vitro T Cell Responses in Mice and Humans of Multiple MHC Types", J. Clin. Invest., 88:876-884 (Sep. 1991).
D. Davis et al, "The Immunodominance of Epitopes within the Transmembrane Protein (gp41) of Human Immunodeficiency Virus Type 1 may be Determined by the Host' Previous Exposure to Similar Epitopes on Unrelated Antigens", J. Gen. Virol., 71(9): 1975-1983 (Sep. 7, 1990).
J. Hunt et al, "Discrimination Between HIV-1 and HIV-2-Seropositive Individuals Using Mouse Monoclonal Antibodies Directed to HIV Transmembrane Proteins", AIDS Research and Human Retroviruses, 6(7): 883-898 (Jul. 1990).
B. Wahren et al, "HIV-1 Peptides Induce a Proliferative Response in Lymphocytes from Infected Persons", J. Acq. Imm. Def. Syn., 4:448-456 (May 1989).
A. Vahlne et al, "Immunizations of Monkeys with Synthetic Peptides Disclose Conserved Areas on gp120 of Human Immunodeficiency Virus Type 1 Associated with Cross-Neutralizing Antibodies and T-Cell Recognition", Proc. Natl. Acad. Sci. USA, 88(23):10744-10748 (Dec. 1, 1991).
N. Shaffer et al, "Maternal Antibodies to V3 Loop Peptides of gp120 are not Associated with Lack of Perinatal HIV-1 Transmission", Abstract No. W.C. 48, VII International Conference on AIDS: Science Challenging AIDS, Florence, Italy (Jun. 1991).
J-P. Allain et al, "Antibody to V3 Loop Peptide does not Predict Vertical Transmission of HIV", Abstract No. W.C.3263, VII International Conference on AIDS: Science Challenging AIDS, Florence, Italy (Jun. 1991).
K. Ugen et al, "Vertical Transmission of Human Retroviral Infections: Immunological Parameters", Archives of STD/HIV Research, 8:283-292 (Nov., 1994).
Ugen Kenneth E.
Weiner David B.
Williams William V.
Nucker Christine M.
Stucker Jeffrey
The Trustees of the University of Pennsylvania
The Wistar Institute of Anatomy & Biology
LandOfFree
Methods and compositions for diagnosing and treating certain HIV does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for diagnosing and treating certain HIV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for diagnosing and treating certain HIV will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-412386