Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-30
2009-11-17
Wollenberger, Louis (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07619081
ABSTRACT:
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to COPB2.
REFERENCES:
patent: 6001992 (1999-12-01), Ackermann
patent: 6111086 (2000-08-01), Scaringe
patent: 6172216 (2001-01-01), Bennett et al.
patent: 6291642 (2001-09-01), Weinstein
patent: 6506559 (2003-01-01), Fire et al.
patent: 6965025 (2005-11-01), Gaarde et al.
patent: 6994979 (2006-02-01), Reed
patent: 7022831 (2006-04-01), Reed
patent: 7022837 (2006-04-01), Harding
patent: 7157570 (2007-01-01), Yun
patent: 2002/0081578 (2002-06-01), Plowman et al.
patent: 2002/0086321 (2002-07-01), Craig
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0150945 (2002-10-01), Finney et al.
patent: 2003/0087259 (2003-05-01), Clancy et al.
patent: 2003/0105051 (2003-06-01), McSwiggen
patent: 2003/0143732 (2003-07-01), Fosnaugh
patent: 2003/0157030 (2003-08-01), Davis et al.
patent: 2003/0228597 (2003-12-01), Cowsert
patent: 2004/0029275 (2004-02-01), Brown et al.
patent: 2004/0054155 (2004-03-01), Woolf et al.
patent: 2004/0063654 (2004-04-01), Davis et al.
patent: 2004/0101857 (2004-05-01), Ward
patent: 2004/0180357 (2004-09-01), Reich et al.
patent: 2004/0192629 (2004-09-01), Xu et al.
patent: 2004/0204380 (2004-10-01), Ackermann
patent: 2004/0219671 (2004-11-01), McSwiggen
patent: 2004/0248296 (2004-12-01), Beresford
patent: 2004/0248299 (2004-12-01), Jayasena et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0048529 (2005-03-01), McSwiggen
patent: 2005/0107328 (2005-05-01), Wyatt
patent: 2005/0130181 (2005-06-01), McSwiggen
patent: 2005/0176025 (2005-08-01), McSwiggen et al.
patent: 2005/0181382 (2005-08-01), Zamore et al.
patent: 2005/0186586 (2005-08-01), Zamore et al.
patent: 2005/0227935 (2005-10-01), McSwiggen
patent: 2005/0239731 (2005-10-01), McSwiggen et al.
patent: 2005/0245475 (2005-11-01), Khvorova
patent: 2006/0286575 (2006-12-01), Farrell
patent: 2007/0031844 (2007-02-01), Khvorova et al.
patent: 2007/0254850 (2007-11-01), Lieberman
patent: WO9800532 (1998-01-01), None
patent: WO0020645 (2000-04-01), None
patent: WO0021559 (2000-12-01), None
patent: WO0076497 (2000-12-01), None
patent: WO 0244321 (2002-06-01), None
patent: WO03035869 (2003-05-01), None
patent: WO03035870 (2003-05-01), None
patent: WO2004046324 (2003-06-01), None
patent: WO03070897 (2003-08-01), None
patent: WO03070969 (2003-08-01), None
patent: WO03646625 (2003-08-01), None
patent: WO03072704 (2003-09-01), None
patent: WO2004031237 (2004-04-01), None
patent: WO2004048511 (2004-06-01), None
patent: WO2004090105 (2004-10-01), None
patent: WO2005001043 (2005-01-01), None
patent: WO2005078095 (2005-08-01), None
patent: WO2005089224 (2005-09-01), None
patent: WO2005117991 (2005-12-01), None
patent: WO2006015389 (2006-02-01), None
patent: WO2006110813 (2006-10-01), None
GenBank Accession No. NM—004766 “Homo sapienscoatomer protein complex, subunit beta 2 (beta prime)(COPB2) mRNA,” as published online May 7, 1999, retrieved from the Nation Center for Biotechnology Information [online] on Dec. 2, 2008 at ncbi.nlm.nih.gov/entrez.
Elbashir et al. et al. (2002) Methods 26:199-213.
Harborth et al. et al. (2001) J. Cell Sci. 114:4557-4565.
Reynolds, et al., Rational siRNA design for RNA interference, Nature Biotechnology, Mar. 2004, vol. 22, No. 3, pp. 326-330.
Ui-Tei et al. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference, Nucleic Acids Research, Feb. 2004, vol. 32, No. 3, pp. 936-948.
Tusterman, et al., Dicers at RISC: The Mechanism of RNAi, Cell, Apr. 2004, vol. 117, pp. 1-4.
Brusca, John S., PCT International Search Report, United States Patent and Trademark Office, Sep. 24, 2007.
Epps-Ford, Janet L., PCT International Search Report, United States Patent and Trademark Office, Feb. 25, 2005.
Kasif, et al., A Computational Framework for Optimal Masking in the Synthesis of Oligonucleotide Microarrays, Nucleic Acids Research, 2002, vol. 30, No. 20, pp. 1-6.
Khvorova, et al., Functional siRNAs and miRNAs Exhibit Strand Bias, Cell, Oct. 2003, vol. 115, pp. 209-216.
Amarzguioui, et al., Secondary Structure Prediction and in vitro Accessibility of mRNA as Tools in the Selection of Target Sites for Ribozymes, Nucleic Acids Research, 2000, vol. 28, No. 21, pp. 4113-4124.
Elbashir, et al., Analysis of Gene Function in Somatic mammalian Cells using small Interfering RNAs, Methods, 2000, vol. 26, pp. 199-213.
Elabashir, et al., Functional Anatomy of siRNAs for Mediating Efficient RNAi in Drosophila Melanogaster Embryo Lysate, European Molecular Biology Organization, 2001, pp. 6877-6888.
Abeliovich, et al. (2000) Mice Lacking Alph-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System. Neuron v.25:239-52.
Amarzguioui M et al, Tolerance for mutations and chemical modifications in a siRNA Nucleic Acids Research vol. 31, No. 2, Jan. 15, 2003 pp. 589-595 , XP002270887 ISSN: 0305-1048.
Bass, B.L., (2001) The Short Answer, Nature V.411:428-29.
Betrand (2002) Comparison of Antisense Oligonucleotides and siRNAs in cell culture and in vivo, Biotechnical and Biophysicial Research Communication 296:1000-1004.
Boutla, Shot 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila, 1776-1780 (Brief Communication) (2001).
Brown et al. (1997) Identification and cDNA Cloning of a Novel Mammalian C2 Domain-Containing Phosphoinositide 3-kinase, HsC2-PI3K. Biochemical and Biophysical Research Communications. 233, 537-544.
Brummelkarna et al. A System for Stable Expression of Short lntereferring RNAs in Mammalian Cells, Science vol. 296 pp. 550-553 (2002).
Cahill et al. (1999) Genomics. 58:181-187.
Caplen et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate systems, Proc. Natl. Acad. Sci USA vol. 98, pp. 9742-9747 (2001).
Caplen, dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for analysis of RNA interference. (2000).
Caplen, RNAi as a gene therapy approach (2003).
Chalk, siRNA db: a database of siRNA sequences (2004).
Chen et al. (2005) TSSK5, A Novel Member of the Testis-Specific Serine/Threonin Kinase Family, Phosphorylates CREB at Ser-122, and Stimulates the CRE-CREB Responsive Pathway. Biochemical and Biophysical Research Communications. 333: 742-749.
Cherry, Michael J. (1995) Computer Manipulation of DNA and Protein Sequences. Current Protocols in Molecular Biology. 7.7.1-7.7.23.
Chi, Genomewide view of gene silencing by small interfering RNAs (2003).
Chinault, Overlap Hybridization Screening: Isolation and Characterization of Overlapping DNA Framgments Surroungin the leu2 Gene on Yeast Chromosome III (1979), 5(2):111-26.
Daniel et al., Specific association of Type I with Ran GTPase in lipopolysacchardie-mediated differentiation, Oncogene 2001, vol. 20: 2618-2625.
Dodelet et al. (2000) Eph Receptors and Ephrin Ligands: embryogenesis to tumorigenesis. Oncogene 19:5614-5619.
Domin et al.(1997) Cloning of Human Phosphoinositide 3-Kinase with a C2 Domain that Displays Reduced Sensitivity to the Inhibitor Wortmannin. Biochem. J., v.325:139-47.
Dottori, et al. (1998) EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract, Proc. Natl. Acad. Sci. vol. 95, pp. 13248-13253, Neurobiology.
Ekholm, et al.(2004) Deregulation of Cyclin E in Human Cells Interferes with Prereplication Complex Assembly. The Journal of Cell Biology. vol. 165, pp. 789-800.
Elbashir et al. (2001) Duplexes of 21-Nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells. Nature vol. 411, pp. 494-498.
El Touny, et al. (2006) Identification of Both Myt-I and Wee-I as Necessary Mediators of the P2I-Independent Inactivation of the Cdc-2/Cyclin BI complex and Growth Inhibition of TRAMP Cancer Cells by Genistein. The Prostate, vol. 66:1542-15
Khvorova Anastasia
Leake Devin
Marshall William
Read Steven
Reynolds Angela
Dharmacon, Inc.
Kalow & Springut LLP
Locke, Esq. Scott D.
Wollenberger Louis
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