Compositions with hematopoietic and immune activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S278100, C424S192100

Reexamination Certificate

active

07632810

ABSTRACT:
The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hemtopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.

REFERENCES:
patent: 5240848 (1993-08-01), Keck et al.
patent: 5332671 (1994-07-01), Ferrara et al.
patent: 6020473 (2000-02-01), Keyt et al.
patent: 6485938 (2002-11-01), Sheppard et al.
patent: 7060278 (2006-06-01), Ferrara et al.
patent: 7264801 (2007-09-01), Ferrara et al.
patent: 2002/0115610 (2002-08-01), Zhou et al.
patent: 2003/0027998 (2003-02-01), Holtzman et al.
patent: 2003/0171306 (2003-09-01), Davis et al.
patent: WO 97/08313 (1997-03-01), None
patent: WO 98/10071 (1998-03-01), None
patent: WO 99/06550 (1999-02-01), None
patent: WO 99/63088 (1999-12-01), None
patent: WO 00/52022 (2000-09-01), None
patent: WO 00/53753 (2000-09-01), None
patent: WO 00/63380 (2000-10-01), None
patent: WO 00/70049 (2000-11-01), None
patent: WO 00/73454 (2000-12-01), None
patent: WO 00/75327 (2000-12-01), None
patent: WO 01/36465 (2001-05-01), None
patent: WO 01/40466 (2001-06-01), None
patent: WO 01/93983 (2001-12-01), None
patent: 02/00711 (2002-01-01), None
patent: WO 02/00690 (2002-01-01), None
patent: WO 02/00711 (2002-01-01), None
patent: WO 02/08284 (2002-01-01), None
patent: WO 02/08288 (2002-01-01), None
patent: WO 02/36625 (2002-05-01), None
patent: 03/020892 (2003-03-01), None
patent: WO 03/020892 (2003-03-01), None
Ju et al. (Proc Nat'l Acad Sci U S A. Apr. 1, 1991;88(7):2658-62).
Kruse et al. (EMBO J. Sep. 1992;11(9):3237-44).
LeCouter et al. “Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis” Nature Medicine, vol. 8, No. 9, Sep. 2002 pp. 913-917.
Wechselberger et al. “The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes” FEBS Letters, vol. 462, No. 1-2, Nov. 26, 1999, pp. 177-181.
LeCouter et al. “Identification of an angiogenic mitogen selective for endocrine gland endothelium” Nature, vol. 412, No. 6850, Aug. 30, 2001, pp. 877-884.
Gerber and Ferrara, 2003,J. mol. Med., 81:20-31 “The role of VEGF in normal and neoplastic hematopoiesis.”
Janowska-Wieczorek et al., 2001,Stem Cells, 19:99-107 “Autocrine/Paracrine Mechanisms in Human Hematopoiesis.”
LeCouter et al., 2003,Proc. Natl. Acd. Sci. USA, 100:2685-2690 “The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.”
Leung et al., 1989,Science, 246:1306-1309 “Vascular Endothelial Growth Factor is a Secreted Anigogenic Mitogen.”
Lin et al., 2002,J. Biol. Chem., 277:19276-19280.
Masuda et al., 2002,Biochem. Biophsy. Res. Commun., 293:396-402.“Isolation and identification of EG-VEGF/prokineticins ascognate ligands for two orphan G-protein-coupled receptors.”
Mollay et al., 1999,Eur. J. Pharamcol., 374:189-196 “Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats.”
Zhou et al., 2001,Mol. Pharmacol., 59:692-698 “Identification of Two Prokineticin cDNAs: Recombinant Proteins Potently Contract Gastrointestinal Smooth Muscle.”
Kaser et al., 2003,EMBO Reports, 4:469-473.
Kisliouk et al., 2005,Endocrinology, 146:3950-3958.
LeCouter et al., 2003,Endocrinology, 144:2606-2616.
Li et al., 2001,Mol. Pharmacol., 59:692-698.
Negri et al., 2005,Brit. J. Pharmacol., 146:625-632.

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