Methods for producing nateglinide B-type crystals

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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C562S444000, C562S445000

Reexamination Certificate

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07544834

ABSTRACT:
A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.

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patent: 63-54321 (1988-03-01), None
U.S. Appl. No. 11/757,769, filed Jun. 4, 2007, Sumikawa et al.

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