Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-10-28
2009-11-24
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S365000
Reexamination Certificate
active
07622592
ABSTRACT:
Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.
REFERENCES:
patent: 3743738 (1973-07-01), Hoff et al
patent: 5006545 (1991-04-01), Sarkozy et al.
patent: 5215989 (1993-06-01), Baldwin et al.
patent: 5852011 (1998-12-01), Matsunaga et al.
patent: 6025379 (2000-02-01), Iyengar et al.
patent: 6358978 (2002-03-01), Ritzeler et al.
patent: 6410578 (2002-06-01), Bouvier et al.
patent: 519 236 (1979-10-01), None
patent: 0 202 568 (1986-05-01), None
patent: 0 224 249 (1986-11-01), None
patent: 1 198 941 (1970-07-01), None
patent: WO 02/076454 (2002-10-01), None
Horikawa et al., CA 68:59964, 1968.
Brandon, D. L. “Monoclonal Antibody-Based ELISA for Thiabendazole in Liver”. Journal of Agricultural and Food Chem., 1991, vol. 40, No. 9, pp. 1722-1726.
Denham, D.A. et al., Database Caplus, XP002434974, 1983.
Denham, DA et al. The Filaricidal Activity of Some Derivatives of N[2-(4-thiazolyl)Benzimidazol-5-yl] Benzamide Against Brugia Pahangi Adults, 1983, pp. 45-47 vol. 5(1),Meth and Find Extl Clin Pharmacol, only pp. 45 and 46 provided.
Duggan Mark E.
Hanney Barbara
Kim Yun-tae
Spencer Keith L.
Camara Valerie J.
Merck & Co. , Inc.
Panzer Curtis C.
Stockton Laura L.
LandOfFree
Carbonylamino-benzimidazole derivatives as androgen receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbonylamino-benzimidazole derivatives as androgen receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbonylamino-benzimidazole derivatives as androgen receptor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4118777