Method of preparation and composition of a water soluble...

Details Method of preparation and composition of a water soluble... Method of preparation and composition of a water soluble...

2005-11-09

2009-08-25

Tate, Christopher R. (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

C514S470000, C514S731000, C514S732000

Reexamination Certificate

active

07579023

ABSTRACT:
A method for isolating the bioactive component of the water-soluble extract ofUncaria tomentosaknown as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii) using the resulting C-MED-100® to obtain a spotting mixture for thin layer chromatography (TLC); (iii) spotting the C-MED-100® spotting mixture on pre-run TLC plates and eluting the plates to obtain the fluorescing band with Rf=0.2-0.3; (iv) scraping off the Rf=0.2-0.3 band, eluting it in ammonia and freeze drying the eluted band to form a powder; and (v) extracting the powder with methanol to remove solubilized silica gel, concentrating the methanol solution and crystalizing the concentrated solution to obtain the bioactive component. The isolated bioactive component is a quinic acid analog, preferably quinic acid lactone. A pharmaceutical composition comprising a pharmaceutically effective amount of the bioactive component and a nontoxic inert carrier or diluent. The bioactive component may be used to enhance immune competency, treat disorders associated with the immune system, inhibit the inflammatory response, treat disorders associated with the inflammatory response, enhance the anti-tumor response, and treat disorders associated with the response to tumor formation and growth, all in mammals.

REFERENCES:
patent: 6039949 (2000-03-01), Pero
patent: 2005/0176825 (2005-08-01), Pero
Sheng et al. J. Ethnopharmacol. 2000. vol. 69, pp. 115-126.

Affiliated with

Also associated with

Rating

Method of preparation and composition of a water soluble... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparation and composition of a water soluble..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparation and composition of a water soluble... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4117019