Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-07-29
2009-08-04
Chong, Yong S (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S557000, C554S225000
Reexamination Certificate
active
07569609
ABSTRACT:
Formula (I) compounds:wherein R1is alkyl substituted by fluorine(s); R2is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl subsituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3and R4, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof. Also, Formula (X) compounds:wherein n is 0 or 1, R11is hydrogen and chlorine, R5is R7—CH2— or R8, or R5and R11, taken together is alkylidene; R6is hydroxy, alkoxy, alkoxy substituted by phenyl, NR9R10, in which R9, R10is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R9and R10, taken together is a saturated heterocyclic ring or amino acid residue, R7is (i) F—(CH2)m- or F3C—CH2—, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R8is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy. Non-toxic and acid addition salts thereof are useful to prevent and/or treat neurodegenerative disease (e.g., Alzheimer's) and neuronal dysfunction by stroke or traumatic injury (e.g., Multiple sclerosis).
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Kishimoto Kazuo
Ohno Hiroyuki
Ohuchida Shuichi
Tateishi Narito
Chong Yong S
Ono Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
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