Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2004-05-27
2009-10-20
Afremova, Vera (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S370000, C435S366000, C435S325000
Reexamination Certificate
active
07604934
ABSTRACT:
A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile canaliculus; exposing a candidate compound to the culture; and determining an amount of candidate compound in the at least one bile canaliculus, the amount of candidate compound in the at least one bile canaliculus indicating the susceptibility of the candidate compound to biliary excretion. Optionally, the culture of hepatocytes is a long-term culture in a sandwich configuration. The method is particularly applicable to the screening of multiple candidate compounds in a single effort.
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Brouwer Kim L. R.
LeCluyse Edward L.
Liu Xingrong
Afremova Vera
Jenkins Wilson Taylor & Hunt, P.A.
The University of North Carolina at Chapel Hill
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