Sp1 as a marker in diagnosis and prognosis of non-alcoholic...

Details Sp1 as a marker in diagnosis and prognosis of non-alcoholic... Sp1 as a marker in diagnosis and prognosis of non-alcoholic...

2006-03-07

2009-12-15

Cheu, Jacob (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007200, C435S007910, C435S007920

Reexamination Certificate

active

07632649

ABSTRACT:
Phosphorylated Sp1 can be used as a marker for in vitro diagnosis of non-alcoholic steatohepatitis (NASH) as well as a therapeutical target of said condition.

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Ihn et al., “Increased Phosphorylation of Transcription Factor Sp1 in Schleroderma Fibroblasts: Association with Increased Expression of the Type I Collagen Gene,” Arthritis and Rheumatism, vol. 43, No. 10, Oct. 2000, pp. 2240-2247.
Black et al., “Growth/Cell Cycle Regulation of Sp1 Phosphorylation,” Journal of Biological Chemistry, vol. 274, No. 3, Jan. 15, 1999, pp. 1207-1215.
Leggett et al., “Sp1 is Phosphorylated and its DNA Binding Activity Down-Regulated Upon Terminal Differentiation of the Liver,” Journal of Biological Chemistry, American Society of Biolochemical BIologists, vol. 270, No. 43, Oct. 27, 1995, pp. 25879-25884.
Lu et al., “Methionine Adenosyltransferase 1A Knockout Mice are Predisposed to Liver Injury and Exhibit Increased Expression of Genes Involved in Proliferation,” Proceedings of the National Academy of Sciences of USA, vol. 98, No. 10, (May 8, 2001), pp. 5560-5565.
Chu et al., “Sp1: Regulation of Gene Expression by Phosphorylation,” Gene, vol. 348, (Mar. 28, 2005), pp. 1-11.

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