Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-28
2009-02-10
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S395000, C514S322000
Reexamination Certificate
active
07488746
ABSTRACT:
Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent. The substituted thiophene derivatives have the following backbone structure:Medicaments comprising compounds of this type are of use for preventing or treating various disorders, such as, respiratory disorders and snoring, acute and chronic disorders, disorders induced by ischemic and/or reperfusion events and by proliferative or fibrotic events, disorders of the central nervous system and lipid metabolism, diabetes, blood coagulation and infection by parasites.
REFERENCES:
patent: 3758476 (1973-09-01), Lindner et al.
patent: 4215133 (1980-07-01), Stahle et al.
patent: 4882342 (1989-11-01), Von Der Saal et al.
patent: 4927834 (1990-05-01), Leinert et al.
patent: 5576322 (1996-11-01), Takase et al.
patent: 5693652 (1997-12-01), Takase et al.
patent: 5801180 (1998-09-01), Takase et al.
patent: 6005010 (1999-12-01), Schwark et al.
patent: 6060607 (2000-05-01), Brands et al.
patent: 6737423 (2004-05-01), Heinelt et al.
patent: 2003/0119754 (2003-06-01), Lackey et al.
patent: 2004/0224965 (2004-11-01), Gericke et al.
patent: 2004/0242627 (2004-12-01), Suzuki et al.
patent: 2004/0254376 (2004-12-01), Suzuki et al.
patent: 2005/0004197 (2005-01-01), Suzuki et al.
patent: 2005/0004204 (2005-01-01), Suzuki et al.
patent: 19960204 (2001-06-01), None
patent: 0339814 (1990-11-01), None
patent: 0400835 (1990-12-01), None
patent: 0419210 (1991-03-01), None
patent: 0681006 (1995-11-01), None
patent: 0825178 (2001-06-01), None
patent: WO 82/02046 (1982-06-01), None
patent: WO 92/08693 (1992-05-01), None
patent: WO 96/14319 (1996-05-01), None
patent: WO 98/56376 (1998-12-01), None
patent: WO 99/24407 (1999-05-01), None
patent: WO 00/35860 (2000-06-01), None
patent: WO 01/21160 (2001-03-01), None
patent: WO 0121582 (2001-03-01), None
patent: WO 01/52847 (2001-07-01), None
patent: WO 0172742 (2001-10-01), None
patent: WO 0179186 (2001-10-01), None
patent: WO 02/30357 (2002-04-01), None
patent: WO 02/30358 (2002-04-01), None
patent: WO 02/053156 (2002-07-01), None
patent: WO 02/053158 (2002-07-01), None
patent: WO 02/053161 (2002-07-01), None
patent: WO 02/072538 (2002-09-01), None
Akhter, S., et. al., Squalamine, A Novel Cationic Steroid, Specifically Inhibits The Brush-Border Na+/H+ Exchanger Isoform NHE3, The American Physiological Society, 276, (Cell Physiology 45), (1999) pp. C136-C144.
Dear, R.E.A., et. al., Reactiones Organicae, Synthesis, 1974, pp. 41-42.
Ernsberger, P., et. al., Clonidine Binds To Imidazole Binding Sites As Well As alpha2-Adrenoceptors In The Ventorolateral Medulla, European Journal Of Pharmacology, 134, 1, (1987) pp. 1-13.
Fliegel, L., et. al., Regulation And Characterization Of The Na+/H+ Exchanger, Biochem. Cell Biology, 76, (1998), pp. 735-741.
Golub, T.R., et. al., Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, Science; Oct. 15, 1999; vol. 286; pp. 531-537.
Jen, T., et. al., Amidines And Related Compounds. 6. Studies On Structure-Activity Relationships Of Antihypertensive And Antisecretory Agents Related To Clonidine, Journal of Medicinal Chemistry, 18, 1, (1975), pp. 90-99.
Ma, E., et al., Expression And Localization Of Na+/H+ Exchangers In Rat Central Nervous System, Neuroscience, 79, 2, (1997), pp. 591-603.
Omar, A-Moshen, M.E. et. al., The Cyclodesulfurization Of Thio Compounds; XVI Dicyclohexylcarbodiimide As An Efficient Cyclodesulfurizing Agents In The Synthesis Of Heterocyclic Compounds From Various Thio Compounds, Synthesis, 1977, pp. 864-865.
Orlowski, J., et. al., Molecular Cloning Of Putative Members Of The Na/H Exchanger Gene Family, The Journal Of Biological Chemistry, 267, 13, (May 5, 1992), pp. 9331-9339.
Staab, H. A., et. al., Synthese Von Isothiocyanaten, Justus Liebigs Annalen Der Chemie, 657, (1962) pp. 104-107.
Bleich Markus
Gekle Michael
Heinelt Uwe
Hofmeister Armin
Lang Hans-Jochen
Bell Craig M.
sanofi-aventis Deutschland GmbH
Stockton Laura L.
LandOfFree
Substituted thiophenes: compositions, processes of making,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted thiophenes: compositions, processes of making,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted thiophenes: compositions, processes of making,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4112893