Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Reexamination Certificate
2002-07-02
2009-02-24
Gabel, Gailene R (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
C435S007100, C435S007920, C435S013000, C435S287200, C435S971000, C435S973000, C436S506000, C436S517000, C436S524000, C436S525000, C436S526000, C436S527000, C436S528000, C436S529000, C436S530000, C436S531000, C436S532000, C436S533000, C436S534000, C436S538000, C436S547000, C436S548000, C436S016000, C436S069000
Reexamination Certificate
active
07494782
ABSTRACT:
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing patient risk for hypercoagulation or other coagulopathies, and monitoring patients for factor VIIa-antithrombin complexes over time which can reveal changes in risk for hypercoagulation or other coagulopathies and/or effectiveness of anticoagulant therapy. Antibodies suitable for use in an in vitro assay for determining the concentration of factor VIIa-antithrombin complexes and methods for making the same are also disclosed.
REFERENCES:
patent: 5248596 (1993-09-01), Esmon et al.
patent: 5741658 (1998-04-01), Morrissey
patent: 5843442 (1998-12-01), Soule et al.
patent: 6492185 (2002-12-01), Kundu
patent: 0090505 (1983-10-01), None
patent: 0278776 (1988-08-01), None
Kondo et al., Regulation of Factor VIIa Activity in Plasma: Evidence that Antithrombin III is the sole plasma protease inhibitor of human factor VIIa, Thrombosis Research, 46: 325-335 (1987).
Goding, J.W., Monoclonal Antibodies: Principles and Practice. Academic Press, London (1983), pp. 56-97.
Hui et al., Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen, Science 222: 1129-1132 (Dec. 9, 1983).
Amiral, J. and Fareed, J. (1966). “Thromboembolic diseases: biochemical mechanisms and new possibilities of biological diagnosis,”Semin Thromb Hemost22 Suppl, 1:41-48.
Bauer, K.A. 1994. “New markers for in vivo coagulation,”Curr Opin Hematol1:341-346.
Bauer, K.A. 1999. “Activation markers of coagulation,”Baillieres Best Pract Res Clin Haematol12:387-406.
Cooper, J.A. et al. 2000. “Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease,”Circulation102:2816-2822.
De Boer, J.P. et al. 1993. “Activation patterns of coagulation and fibrinolysis in baboons following infusion with lethal or sublethal dose ofEscherichia coli,” Circ Shock39:59-67.
Drake, T.A. et al. 1993. “Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethalEscherichia colisepsis,”Am J Pathol142:1458-1470b.
Gouin-Thibault, I. et al. 1995. “Measurement of factor Xa-antithrombin III in plasma: relationship to prothrombin activation in vivo,”Br J Haematol90:669-680.
Gouin-Thibault, I. and Samama, M.M. 1999. “Laboratory diagnosis of the thrombophilic state in cancer patients,”Semin Thromb Hemost25: 167-172.
Hamamoto, T. and Kisiel, W. 1998. “The effect of cell surface glycosaminoglycans (GAGS) on the inactivation of factor VIIa-tissue factor activity by antithrombin III,”Int J Hematol68:67-78.
Iversen, N. et al. 2000. “Tissue factor pathway inhibitor (TFPI) in disseminated intravascular coagulation: low levels of the activated factor X-TFPI complex,”Blood Coagul Fibrinolysis11:591-598.
Kondo, S. and Kisiel, W. 1987. “Regulation of factor VIIa in plasma: Evidence that antithrombin III is the sole plasma proteinase inhibitor of human factor VIIa,”Thromb Res46:325-335.
Lawson, J.H. et al. 1993. “Complex-dependent inhibition of factor VIIa by antithrombin III and heparin,”J Biol Chem268:767-770.
Miller, G.J. 2000. “Haemostatic factors in human peripheral afferent lymph,”Thromb Haemost83:427-432.
Morrissey, et al. 1987. “Molecular cloning of the cDNA for tissue factor, the cellular receptor for initiation of the coagulation protease cascade,”Cell50:129-135.
Morrissey, J.H. et al. 1993. “Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation,”Blood81:734-744.
Morrissey, J.H. 1996. “Plasma factor VIIa: Measurement and potential clinical significance,”Haemostasis26:66-71.
Morrissey, J.H. 2001. “Tissue factor and factor VII initiation of coagulation,” inHemostasis and Thrombosis: Basic Principles and Clinical Practice, R.W. Colman et al. eds., Philadelphia: Lippincott Williams & Wilkins, pp. 89-101.
Neuenschwander P.F. et al. 1993. “Importance of substrate composition, pH and other variables on tissue factor enhancement of factor VIIa activity,”Thromb Haemost70:970-977.
Okugawa, Y. et al. 2000. “Increased plasma levels of tissue factor pathway inhibitor-activated factor X complex in patients with disseminated intravascular coagulation,”Am J Hematol65:210-214.
Rao, L.V.M. et al. 1993. “Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa,”Blood81:2600-2607.
Takahashi, et al. 1991. “Activated factor IX-antithrombin III complexes in human blood: quantification by an enzyme-linked differential antibody immunoassay and determination of the in vivo half-life,”J Lab Clin Med118:317-325.
Taylor, F.B. et al. 1991. “LethalE. coliseptic shock is prevented by blocking tissue factor with monoclonal antibody,”Circ Shock33:127-134.
Taylor, F.B et al. 2001. “Two-stage response to endotoxin infusion into normal human subjects: Correlation of blood phagocyte luminescence with clinical and laboratory markers of the inflammatory, hemostatic response,”Crit Care Med29:326-334.
Esmon, CT. 2000. “Regulation of blood coagulation,”Bichimica et Biophysica Acta1477:349-360.
Gabel Gailene R
Hansen Eugenia S.
Hemingway & Hansen LLP
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