Heterodimers and methods of using them

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S141000

Reexamination Certificate

active

07605265

ABSTRACT:
Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.

REFERENCES:
patent: WO2006/127748 (2006-11-01), None
Carlier et al.Bioorganic and Medicinal chemistry Letters, 9(16), 2335-2338, 1999.
International Search Report from PCT/US2008/051717 dated May 28, 2008, mailed Jun. 2, 2008.
Carlier, P.R. et al: “Potent, Easily Synthesized Huperzine A-Tacrine Hybrid Acetylcholinesterase Inhibitors,” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 9, No. 16, Aug. 16, 1999, pp. 2335-2338, XP004174186, ISSN: 0960-894X.
Written Opinion of the International Searching Authority.

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