Process for identifying substances which modulate the...

Details Process for identifying substances which modulate the... Process for identifying substances which modulate the...

2005-03-24

2009-06-23

Kemmerer, Elizabeth C. (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S040000, C435S404000, C530S350000

Reexamination Certificate

active

07550257

ABSTRACT:
The present invention provides a process for identifying substances that modulate the activity of hyperpolarization-activated cation channels, and the use of this process.

REFERENCES:
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patent: WO 00/63349 (2000-10-01), None
patent: WO 00/73431 (2000-12-01), None
Biel et al., Hyperpolarization-Activated Cation Channels: A Multi-Gene Family, Rev. Physiol. Biochem. Pharmacol. vol. 136, 1999, pp. 165-181.
Hamill et al., Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches, Pfluegers Arch. vol. 391, 1981, pp. 85-100.
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Langheinrich et al., Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation, J. of Physiolog, vol. 502.2, 1997, pp. 397-408.
Ludwig et al., Two Pacemaker Channels from Human Heart with Profoundly Different Activation Kinetics, EMBO J., vol. 18, No. 9, 1999, pp. 2323-2329.
Vaccari et al., The Human Gene Coding for HCN2, a Pacemaker Channel of the Heart, Biochim et Biophys. Acta vol. 1446, No. 3, 1999, pp. 419-425.

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