Aryl carbamate oligomers for hydrolyzable prodrugs and...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C560S029000, C564S156000, C564S177000, C568S650000

Reexamination Certificate

active

07625995

ABSTRACT:
The present invention provides a compound having a formula: where R1is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and —(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula:in-line-formulae description="In-line Formulae" end="lead"?-L-O-PAGR.R2]qin-line-formulae description="In-line Formulae" end="tail"?where L is a optional linker moiety selected from the group consisting of —CH2O—, —CH2OX—, —OX—, —C(O)—, —C(O)X, —NH—, —NHC(O)—, —XNHC(O)—, —NHC(O)X—, —C(O)NH—, —C(O)NHX—, andwhere X is alky1-6or is not present, Y is N or O or is not present, and R3is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2is an alkyl1-22capping moiety if X is present or alkyl2-22if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.

REFERENCES:
patent: 4145342 (1979-03-01), Trautner et al.
patent: 5389626 (1995-02-01), Kojima et al.
patent: 6232320 (2001-05-01), Stewart et al.
patent: 6413507 (2002-07-01), Bentley et al.
patent: 2822191 (1979-11-01), None
patent: 0153642 (1985-09-01), None
patent: 0064876 (1986-08-01), None
patent: 51092831 (1976-08-01), None
patent: 57163596 (1982-10-01), None
patent: 05135769 (1993-06-01), None
patent: 9308196 (1993-04-01), None
patent: 95-29975 (1995-11-01), None
patent: 9838152 (1998-09-01), None
patent: 99-30727 (1999-06-01), None
patent: 02102897 (2002-12-01), None
Michael Roberts et al.; Molecule Engineering Including Advanced PEGylation: Understanding the Full Potential; The Drug Delivery Companies Report Spring/Summer 2003; pp. 19-21; USA.
Richard B. Greenwald et al.; Effective Drug Delivery by PEGylated Drug Conjugates; Advanced Drug Delivery Reviews; 2003; 55; pp. 217-250; Elsevier Science B.V.
Richard B. Greenwald et al.; Drug Delivery Systems Employing 1,4- or 1.6-Elimination: Poly(ethylene glycol) Prodrugs of Amine-Containing Compounds; J. of Medicinal Chemistry; 1999; vol. 42; pp. 3657-3667; American Chemical Society.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Aryl carbamate oligomers for hydrolyzable prodrugs and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aryl carbamate oligomers for hydrolyzable prodrugs and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryl carbamate oligomers for hydrolyzable prodrugs and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4105552

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.