Certain 7-.alpha.-substituted-.alpha.-hydroxyacetamido-3-(1-carb

Details Certain 7-.alpha.-substituted-.alpha.-hydroxyacetamido-3-(1-carb Certain 7-.alpha.-substituted-.alpha.-hydroxyacetamido-3-(1-carb

1976-07-28

1979-10-23

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 27, 424246, C07D50136

Patent

active

041721969

ABSTRACT:
Certain 7-acylamido-3-(1-carboxymethyltetrazol-5-yl-thiomethyl)-3-cephem-4-carboxy lic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent anti-bacterial agents which exhibited good aqueous solubilty. In a preferred embodiment the 7-substituent was D-.alpha.-hydroxyphenylcetamido.

REFERENCES:
patent: 3989694 (1976-11-01), Berges

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