Method for proliferating natural killer cells

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C435S325000

Reexamination Certificate

active

07629316

ABSTRACT:
Natural Killer (NK) cells are obtained by administering a Toll-like receptor ligand such as polyinosinic-polycytidylic acid into the peritoneal cavity of an animal to which lactoferrin has been administered to proliferate NK cells in the peritoneal cavity and collecting NK cells from the peritoneal cavity.

REFERENCES:
patent: 1 790 355 (2007-05-01), None
patent: 2001-503430 (2001-03-01), None
patent: 2001-149069 (2001-06-01), None
patent: 2002-515893 (2002-05-01), None
patent: WO 98/19675 (1998-05-01), None
patent: WO 98/33509 (1998-08-01), None
patent: WO 02/47612 (2002-06-01), None
Teraguchi, et al. “Protection Against Infections by Oral Lactoferrin: Evaluation in Animal Models,”BioMetals, vol. 17, No. 3, pp. 231-234, 2004.
Sivori, et al. “CpG and Double-Stranded RNA Trigger Human NK Cells by Toll-Like Receptors: Induction of Cytokine Release and Cytotoxicity Against Tumors and Dendritic Cells,”PNAS, vol. 101, No. 27, 10116-10121, Jul. 6, 2004.
Decicco, et al. “All-trans-retinoic Acid and Polyriboinosinic: Polyribocytidylic Acid in Combination Potentiate Specific Antibody Production and Cell-Mediated Immunity,”Immunology, vol. 104, No. 3, pp. 341-348, 2001.
Kasaian, et al. “Cyclosporin a Inhibition of Interleukin 2 Gene Expression, But Not Natural Killer Cell Proliferation, After Interferon Induction In Vivo,”Journal of Experimental Medicine, vol. 171, pp. 745-762, 1990.
Kuhara, et al. “Oral Administration of Lactoferrin Raises NK Cell Activity in Mice,”Milk Science, vol. 53, No. 4, pp. 262-264, 2004.
Riccardi, et al. “Generation of Mouse Natural Killer (NK) Cell Activity: Effect of Interleukin-2 (IL-2) and Interferon (IFN) on the In Vivo Development of Natural Killer Cells From Bone Marrow (BM) Progenitor Cells,”International Journal of Cancer, vol. 38, pp. 553-562, 1986.
Tsuda, et al. “Inhibition of Carcinogenesis by Bovine Lactoferrin and Analysis of Mechanisms,”FFI Journal, No. 200, pp. 27-35, 2002 (in Japanese).
Tsuda, et al. “Cancer Prevention by Bovine Lactoferrin and Underlying Mechanisms—A Review of Experimental and Clinical Studies,”Biochem. Cell Biol., vol. 80, pp. 131-136, 2002.
Wang, et al. “Activation of Intestinal Mucosal Immunity in Tumor-Bearing Mice by Lactoferrin”Japanese Journal of Cancer Research, vol. 91, pp. 1022-1027, Oct. 2000.
Porgador, et al. “Natural Killer Cell Lines Kill Autologous β2-Microglobulin-Deficient Melanoma Cells: Implications for Cancer Immunotherapy,”Proc. Natl. Acad. Sci., USA, vol. 94, pp. 13140-13145, 1997.
Hemmi and Akira,Molecular Medicine, vol. 39, pp. 238-246, 2002.
Akira, S.,Molecular Medicine, vol. 40, pp. 186-193, 2003.
Schmidt, et al. “APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA,”The Journal of Immunology, vol. 172, pp. 138-143, 2004.
Hébert, et al. “Ethanol Decreases Natural killer Cell Activation but Only Minimally Affects Anatomical Distribution After Administration of Polyinosinic:Polycytidylic Acid: Role in resistance to B16F10 Melanoma,”Alcoholism Clinical and Experimental Research, vol. 27, No. 10, pp. 1622-1631, Oct. 2003.
Collier, et al. “Mechanisms of Suppression of Poly I:C-induced Activation of NK Cells by Ethanol,”Alcohol, vol. 21, pp. 87-95, 2000.
Kuhara, et al. “Oral Administration of Lactoferrin Increases NK Cell Activity in Mice via Increased Production of IL-18 and Type I IFN in the Small Intestine,”Journal of Interferon&Cytokine Research, vol. 26, No. 7, pp. 489-499, Jul. 2006.
Shimizu, et al. “Lactoferrin-mediated Protection of the Host from Murine Cytomegalovirus Infection by a T-cell—dependent Augmentation of Natural Killer Cell Activity,”Archives of Virology, vol. 141, No. 10, pp. 1875-1889, 1996.
Damiens, et al. “Effects of Human Lactoferrin on NK Cell Cytotoxicity Against Haematopoietic and Epithelial Tumour Cells,”Biochimica et Biophysica Acta, vol. 1402, No. 3, pp. 277-287, Apr. 24, 1998.
Supplementary Partial European Search Report, dated Jun. 25, 2009.

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