Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2007-10-15
2009-08-11
Oh, Taylor Victor (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C560S053000
Reexamination Certificate
active
07572829
ABSTRACT:
The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric,gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
REFERENCES:
patent: 5089636 (1992-02-01), Kwak et al.
patent: 5266344 (1993-11-01), Mimura et al.
patent: 5587358 (1996-12-01), Sukigara et al.
patent: 6887898 (2005-05-01), Kim
patent: 7279501 (2007-10-01), Kim
patent: 7282523 (2007-10-01), Kim
patent: 2004/0010578 (2004-01-01), Demetriades et al.
patent: 2004/0101578 (2004-05-01), Kim et al.
patent: 2006/0148905 (2006-07-01), Kim
patent: 02-193930 (1990-07-01), None
patent: 07206669 (1995-08-01), None
patent: 08-040970 (1996-02-01), None
patent: 11246398 (1999-09-01), None
patent: WO-97/03674 (1997-02-01), None
patent: WO-98/51302 (1998-11-01), None
patent: WO-00/70949 (2000-11-01), None
Artico et al., “Geometrically and Confromationally Restrained Cinnamoyl Compounds as Inhibitors of HIV-1 Integrase: Synthesis, Bioligical Evaluation, and Molecular Modeling,”J. Med. Chem., 41:3948-3960 (1998).
Chang et al., “The Effect of Chinese Medicinal HerbZingiberis rhizomaExtract on Cytokine Secretion by Human Peripheral Blood Mononuclear Cells,”J. Ethnopharmacology, 48:13-19 (1995).
Clostre, “Ginkgo bilobaextract (EGb 761): A State of Art at the Drawn of the Third Millennium,” Annales Pharmaceutiques Francaises, 57, No. Suppl. 1:1S8-1S88 (1999).
Conney et al., “Inhibitory Effect of Curcumin and Some Related Dietary Compounds on Tumor Promotion and Arachidonic Acid Metabolism in Mouse Skin,”Advances in Enzyme Regulation, Proceedings of the Thirty-First Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues held at Indiana University School of Medicine, Weber, ed., vol. 31, pp. 385-396 (1991).
Gellerman et al., “Antimicrobial Effects of Anacardic Acids,”Canadian Journal of Microbiology, 15:1219-1223 (1969).
He et al., “High-Performance Liquid Chromatography-Electrospray Mass Spectrometric Analysis of Pungent Constituents of Ginger,”J. Chromatography A, 796:327-334 (1998).
Hiserodt et al., “Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition ofMycobacterium aviumandMycobacterium tuberculosis,”J. Agric. Food Chem., 46:2504-2508 (1998).
Huang et al., “Novel Bipheny Ether Liganans from the Rhizomes ofCurcuma chuanyujin”Chem. Pharm. Bull, 48(8):1228-1229 (2000).
Itokawa et al., “Antitumor Principles fromGinkgo bilobaL.,”Chem. Pharm.Bull., 35(7):3016-3020 (1987).
Jung et al., “Effects of Curcumin on the Microglial Activation,”Yakhak Hoeji, 44(5):448-454 (2000).
Kelloff et al., “Chemopreventive Drug Development: Perspectives and Progress,”Cancer Epidemiol. Biomarkers&Prev., 3:85-98 (1994).
Khopde et al., “Free Radical Scavenging Ability and Antioxidant Efficiency of Curcumin and its Substituted Analogue,”Biophysical Chemistry, 80:85-91 (1999).
Kim et al., “Inhibition of β-Amyloid Neurotoxicity in PC12 Cells by CLZ-1, CLZ-2 and CLZ-3 Isolated FromCurcuma longa, Zingiberaceae: An Approach Toward A Rational Drug Discovery Of Anti-Alzheimer Disease,”Society For Neuroscience Abstracts, 24(1-2):1457 (1998).
Kim et al., “Curcuminoids fromCurcuma longaL. (Zingiberaceae) that Protect PC12 Rat pheochromocytoma and Normal Human Umbilical Vein Endothe4lial Cells from βA(1042) Insult,”Neuroscience Letters, 303:57-61 (2001).
Kim et al., “Total Synthesis of Calebin-A, Preparation of Its Analogues, and Their Neuronal Cell Protectivity Against β-Amyloid Insult,” Bioorg. Med. Chem. Lett., 11:2541-2543, 2001.
Kuner et al., “β-Amyloid Binds to p75NTRand Activates NFκB in Human Neuroblastoma Cells,”J. Neuroscience Res., 54:798-804 (1998).
Lee et al., “Induction of Apoptosis in HL-60 Cells by Pungent Vanilloids, [6]-gingerol and [6]-paradol, ”Cancer Letters, 134:163-168 (1998).
Lim et al., “Prevention of LTP deficits in Alzheimer Ttransgenic HuAPPSw Mice Using a Phenolic Anti-oxidant/anti-inflammatory Compound,”Society for Neuroscience Abstracts, 26(1-2):Abstract No. 763.9 (2000).
Maurer et al., “Clinical Efficacy ofGinkgo bilobaSpecial Extract EGb 761 in Dementa of the Alzheimer Type,”J. Psychiat. Res., 31(6):645-655 (1997).
Morimoto et al., “Sterische Strukture der Giftstoffe aus dem Fruchtfleisch onGinkgo biloba L.,” Chem. Pharm. Bull., 16(11):2282-2286 (1968).
Nagabhushan et al., “Mutagenicity Of Gingerol And Shogaol And Antimutagenicity Of Zingerone In Salmonella/Microsome Assay,”Cancer Letters, 36:221-233 (1987).
Nakayama, “Strategy of Chemical Modification to Free Radical Scavengers for Suppression of Hydrogen Peroxide-Induced Cytotoxicity,”Food Factors Cancer Prev., Int. Conf., 1995, pp. 642-646 (1997).
Niijima et al., “Effect of Oral Administration ofPinellia ternata, Zingiberis rhizomaand Their Mixture on the Efferent Activity of the Gastric Branch of the Vagus Nerve in the Rat,”Neuroscience Letters, 258:5-8 (1998).
Nurfina et al., “Synthesis of Some Symmetrical Curcumin Derivatives and Their Anti-Inflammatory Activity,”Eur. J. Med. Chem., 32:321-328 (1997).
Osawa et al., “Antioxidative Activity of Tetrahydrocurcuminoids,”Biosci. Biotech. Biochem., 59(9):1609-1612 (1995).
Prasain et al., “Inhibitory Effect of Diarylheptanoids on Nitric Oxide Production in Activated Murine Macrophages,”Biol. Pharm. Bull., 21(4):371-374 (1998).
Ruby et al., “Anti-tumor and Antioxidant Activity of Natural Curcuminoids,”Cancer Letters, 94: 79-83 (1995).
Schulick,Ginger, Common Spice&Wonder Drug, 3rdEdition, Hohm Press, pp. 1-166 (1996).
Skolnick, “Old Chinese Herbal Medicine Used for Fever Yields Possible New Alzheimer Disease Therapy,”JAMA, 277(10):776 (1997).
Soliman et al., “In vitro Attenuation of Nitric Oxide Production inC6 Astrocyte Cell Culture by Various Dietary Compounds,”Proc. Soc. Exper. Biol. Med., 218(4):390-397 (1998).
Suekawa et al., “Pharmacological Studies On Ginger. I. Pharmacological Actions Of Pungent Constituents, (6)-Gingerol and (6)-Shogaol,”J. Pharm Dyn., 7:836-848 (1984).
Venkateshwarlu, “Cyclo-Oxygenase Inhibityors From Spices,”Indian Drugs, 34(8):427-432 (1997).
Yoshikawa et al., “Qualitative and Quantitative Analysis of Bioactive Principles inZingiberis rhizomaby Means of High Performance Liquid Chromatography and Gas Liquid Chromatography. On the Evaluation ofZingiberis rhizomaand Chemical Change of ConstituentsduringZingiberis rhizomaProcessing,” Regular Articles,Yakugaku Zasshi, 113:-307-315 (1993).
International Search Report dated Mar. 8, 2002 for International Application No. PCT/US00/41436.
Written Opinion dated Mar. 18, 2002 for International Application No. PCT/US00/41436.
Meda et al., “Activation of Microglial Cells by Beta-amyloid Protein and Interferongamma,”Nature 37, 647-50 (1995).
Larner, “Neurite Growth-inhibitory Properties of Amyloid Beta-peptides in vitro: A Beta 25-35, but not A Beta 1-40, is Inhibitory,”Neurosci Res. Commun. 20(3): 147-155 (1997).
St. George-Hyslop et al., “Alzheimer's Disease. Antibody Clears Senile Plaques,”Nature 400, 116-7 (1999).
International Search Report received in International (PCT) Application No. PCT/US06/23197, dated Oct. 17, 2006.
Locksley et al., “Perkin Transactions,”J. Chem. Soc., 23:3001-3006 (1972).
International Search Report received in International (PCT) Application No. PCT/US06/23124, by the World Intell
Marshall & Gerstein & Borun LLP
Oh Taylor Victor
LandOfFree
Pharmaceutical compositions useful in prevention and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions useful in prevention and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions useful in prevention and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4098723