Process for the preparation of amino methyl cyclo alkane...

Details Process for the preparation of amino methyl cyclo alkane... Process for the preparation of amino methyl cyclo alkane...

2002-11-20

2009-12-22

Sullivan, Daniel M (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C562S507000

Reexamination Certificate

active

07635717

ABSTRACT:
This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid), which is a very well known agent useful for the treatment of epilepsy and other cerebral disorders. In the chemical series of 1-amino methyl cyclo alkane-1-acetic acids, Gabapentin, which is 1-amino methyl cyclo hexane-1-acetic acid has been developed as a drug having anti convulsive properties.

REFERENCES:
patent: 6255526 (2001-07-01), Pesachovich et al.
patent: 6518456 (2003-02-01), Peverali et al.
patent: 2004/0068011 (2004-04-01), Cannata et al.
patent: WO 98/28255 (1998-07-01), None
patent: WO 00/58268 (2000-10-01), None
patent: WO 02/44123 (2002-06-01), None
Sigma-Aldrich #190764, 2-Propanol ACS Reagent 99.5%.
Sigma-Aldrich #667390, Methanol solution.
Sigma-Aldrich #179957, Methanol Laboratory Reagent 99.6%.

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