Glucocorticoid mimetics, methods of making them,...

Details Glucocorticoid mimetics, methods of making them,... Glucocorticoid mimetics, methods of making them,...

2003-12-18

2009-08-25

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07579469

ABSTRACT:
Compounds of Formula (I)wherein R1, R2, R3, R4, R5, R6, and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

REFERENCES:
patent: 4880839 (1989-11-01), Tucker
patent: 5039691 (1991-08-01), Spagnuolo et al.
patent: 6323199 (2001-11-01), Lehmann et al.
patent: 6329534 (2001-12-01), Kym et al.
patent: 6380223 (2002-04-01), Dow et al.
patent: 6436986 (2002-08-01), Kym et al.
patent: 6506766 (2003-01-01), Coghlan et al.
patent: 6583180 (2003-06-01), Link et al.
patent: 6903215 (2005-06-01), Betageri et al.
patent: 2002/0077356 (2002-06-01), Jaroch et al.
patent: 2002/0156311 (2002-10-01), Link et al.
patent: 2003/0232823 (2003-12-01), Betageri et al.
patent: 2004/0010020 (2004-01-01), Kirrane, Jr. et al.
patent: 2004/0010148 (2004-01-01), Kirrane, Jr. et al.
patent: 2004/0029932 (2004-02-01), Bekkali et al.
patent: 2004/0097574 (2004-05-01), Marshall
patent: 900594 (1985-03-01), None
patent: 0 154 528 (1985-03-01), None
patent: 0 154 528 (1985-03-01), None
patent: 0311447 (1989-12-01), None
patent: 0 253 500 (1991-02-01), None
patent: 0 253 503 (1991-12-01), None
patent: 2 146 987 (1984-09-01), None
patent: WO 96/19458 (1996-06-01), None
patent: WO 97/27852 (1997-08-01), None
patent: WO 98/54159 (1998-12-01), None
patent: WO 99/41256 (1999-02-01), None
patent: WO 00/32584 (2000-06-01), None
patent: WO 00/66522 (2000-11-01), None
patent: WO 02/02565 (2002-01-01), None
patent: WO 02/10143 (2002-02-01), None
patent: WO 02064550 (2002-08-01), None
patent: WO 03/059899 (2003-07-01), None
Peeters, Stress, vol. 7(4), pp. 233-241, 2004.
Bekkali, Y., et al; Application entitled Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof, accorded U.S. Appl. No. 10/639,131.
Cywin, C. et al; Application entitled Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof, accorded U.S. Appl. No. 10/785,222.
Hamann, Lawrence, et al ; Discovery of a potent, Orally active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6-(trifluoromethyl)-8-pyridono[5,6-gl-quinoline(LG12107I), J. Med Chem, 1999, 42, 210-212.
Pooley, Charlotte, et al; Discovery and Preliminary SAR Studies of a Novel Nonsteroidal Progesterone Receptor Antagonist Pharmacophore, J. Med. Chem 1998, 41, 3461-3466.
Edwards, James, P. et al; 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally Active, Nonsteroidal Progestgerone Receptor Agonists; The Effect of D-Ring Substituents, J. Med. Chem 1998, 41, 303-310.
Zhi, Lin, et al; 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists, J. Med. Chem 1998, 41, 291-302.
Zhi, Lin; et al 5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a Novel Class Of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification, J. Med. Chem 1999, 42, 1466-1472.
Tegley, Christopher, et al; 5-Benzylidene 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists; J. Med. Chem 1998, 41, 4354-4359.
Edwards, James, P. et al; Preparation, Resolution and Biological Evaluation of 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally Active, Nonsteroidal Progestgerone Receptor Agonists: J. Med. Chem. 1998.41. 2779-2785.
Hamann, Lawrence, et al; Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g] quinolines J. Med. Chem. 1998. 41. 623-639.
Regan, John, et al; Advances Toward Dissociated Non-Steroidal Glucocorticoid Receptor Agonists, Annual Reports in Medicinal Chemistry, vol. 43, pp. 161-151.

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