siRNA targeting TIE-2

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07615541

ABSTRACT:
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.

REFERENCES:
patent: 6001992 (1999-12-01), Ackerman
patent: 6111086 (2000-08-01), Scaringe
patent: 6172216 (2001-01-01), Bennett et al.
patent: 6291642 (2001-09-01), Weinstein
patent: 6506559 (2003-01-01), Fire et al.
patent: 6965025 (2005-11-01), Gaarde et al.
patent: 6994979 (2006-02-01), Reed
patent: 7022831 (2006-04-01), Reed
patent: 7022837 (2006-04-01), Harding et al.
patent: 7157570 (2007-01-01), Yun
patent: 2002/0081578 (2002-06-01), Plowman
patent: 2002/0086321 (2002-07-01), Craig
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0150945 (2002-10-01), Finney et al.
patent: 2003/0087259 (2003-05-01), Clancy et al.
patent: 2003/0105051 (2003-06-01), McSwiggen
patent: 2003/0143732 (2003-07-01), Fosnaugh
patent: 2003/0157030 (2003-08-01), Davis et al.
patent: 2003/0228597 (2003-12-01), Cowsert
patent: 2004/0029275 (2004-02-01), Brown et al.
patent: 2004/0054155 (2004-03-01), Woolf et al.
patent: 2004/0063654 (2004-04-01), Davis et al.
patent: 2004/0077574 (2004-04-01), Klinghoffer
patent: 2004/0101857 (2004-05-01), Ward
patent: 2004/0180357 (2004-09-01), Reich et al.
patent: 2004/0192629 (2004-09-01), Xu et al.
patent: 2004/0204380 (2004-10-01), Ackerman
patent: 2004/0219671 (2004-11-01), McSwiggen
patent: 2004/0248296 (2004-12-01), Beresford
patent: 2004/0248299 (2004-12-01), Jayasena et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0048529 (2005-03-01), McSwiggen
patent: 2005/0107328 (2005-05-01), Wyatt
patent: 2005/0130181 (2005-06-01), McSwiggen
patent: 2005/0176025 (2005-08-01), McSwiggen et al.
patent: 2005/0181382 (2005-08-01), Zamore et al.
patent: 2005/0186586 (2005-08-01), Zamore et al.
patent: 2005/0227935 (2005-10-01), McSwiggen
patent: 2005/0239731 (2005-10-01), McSwiggen et al.
patent: 2005/0245475 (2005-11-01), Khvorova
patent: 2006/0286575 (2006-12-01), Farrell
patent: 2007/0031844 (2007-02-01), Khvorova et al.
patent: 2007/0254850 (2007-11-01), Lieberman
patent: WO9800532 (1998-01-01), None
patent: WO0020645 (2000-04-01), None
patent: WO0021559 (2000-12-01), None
patent: WO0076497 (2000-12-01), None
patent: WO 0244321 (2002-06-01), None
patent: WO03035869 (2003-05-01), None
patent: WO03035870 (2003-05-01), None
patent: WO03070897 (2003-08-01), None
patent: WO03070969 (2003-08-01), None
patent: WO03646625 (2003-08-01), None
patent: WO03072704 (2003-09-01), None
patent: WO2004031237 (2004-04-01), None
patent: WO2004046324 (2004-06-01), None
patent: WO2004048511 (2004-06-01), None
patent: WO2004090105 (2004-10-01), None
patent: WO2005001043 (2005-01-01), None
patent: WO2005078095 (2005-08-01), None
patent: WO2005089224 (2005-09-01), None
patent: WO2005117991 (2005-12-01), None
patent: WO2006015389 (2006-02-01), None
patent: WO2006110813 (2006-10-01), None
Abeliovich, et al. (2000) Mice Lacking Alph-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System. Neuron v.25:239-52.
Amarzguioui M et al, Tolerance for mutations and chemical modifications in a siRNA Nucleic Acids Research vol. 31, No. 2, Jan. 15, 2003 pp. 589-595 , XP002270887 ISSN: 0305-1048.
Bass, B.L., (2001) The Short Answer, Nature V.411:428-29.
Betrand (2002) Comparison of Antisense Oligonucleotides and siRNAs in cell culture and in vivo, Biotechnical and Biophysicial Research Communication 296:1000-1004.
Boutla, Shot 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila, 1776-1780 (Brief Communication) (2001).
Brown et al. (1997) Identification and cDNA Cloning of a Novel Mammalian C2 Domain-Containing Phosphoinositide 3-kinase, HsC2-Pl3K. Biochemical and Biophysical Research Communications. 233, 537-544.
Brummelkarna et al. A System for Stable Expression of Short Intereferring RNAs in Mammalian Cells, Science vol. 296 pp. 550-553 (2002).
Cahill et al. (1999) Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes. Genomics. 58:181-187.
Caplen et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate systems, Proc. Natl. Acad. Sci USA vol. 98, pp. 9742-9747 (2001).
Caplen, dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for analysis of RNA interference, Jul. 11, 2000; Gene; 252(1-2):95-105.
Caplen, RNAi as a gene therapy approach. Expert Opin. Ther. 3(4):575-586. (2003).
Chalk, siRNA db: a database of siRNA sequences. Nucleic Acids Research. vol. 33 pp. D131-D134 (2004).
Chen et al. (2005) TSSK5, A Novel Member of the Testis-Specific Serine/Threonin Kinase Family, Phosphorylates CREB at Ser-122, and Stimulates the CRE-CREB Responsive Pathway. Biochemical and Biophysical Research Communications. 333: 742-749.
Cherry, Michael J. (1995) Computer Manipulation of DNA and Protein Sequences. Current Protocols in Molecular Biology. 7.7.1-7.7.23.
Chi, Genomewide view of gene silencing by small interfering RNAs. PNAS vol. 100, No. 11, pp. 6343-6346 (2003).
Chinault, Overlap Hybridization Screening: Isolation and Characterization of Overlapping DNA Fragments Surrounding the leu2 Gene on Yeast Chromosome III. Gene (1979), 5(2):111-26.
Daniel et al., Specific association of Type I with Ran GTPase in lipopolysacchardie-mediated differentiation, Oncogene 2001, vol. 20: 2618-2625.
Dodelet et al. (2000) Eph Receptors and Ephrin Ligands: embryogenesis to tumorigenesis. Oncogene 19:5614-5619.
Domin et al.(1997) Cloning of Human Phosphoinositide 3-Kinase with a C2 Domain that Displays Reduced Sensitivity to the Inhibitor Wortmannin. Biochem. J., v.325:139-47.
Dottori, et al. (1998) EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract, Proc. Natl. Acad. Sci. vol. 95, pp. 13248-13253, Neurobiology.
Ekholm, et al.(2004) Deregulation of Cyclin E in Human Cells Interferes with Prereplication Complex Assembly. The Journal of Cell Biology. vol. 165, pp. 789-800.
Elbashir et al. (2001) Duplexes of 21-Nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells. Nature vol. 411, pp. 494-498.
El Touny, et al. (2006) Identification of Both Myt-I and Wee-I as Necessary Mediators of the P2I-Independent Inactivation of the Cdc-2/Cyclin BI complex and Growth Inhibition of TRAMP Cancer Cells by Genistein. The Prostate, vol. 66:1542-1555.
European Patent Office, European Patent Application No. 03786798.3 Office Action dated Nov. 15, 2007.
Far, R-K, The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides (2003) Nucleic Acids Research. vol. 31, No. 15, pp. 4417-4424.
Feng, et al. (2003) Inhibiting the Expression of DNA Replication-Initiation Proteins Induces Apoptosis in Human Cancer Cells. Cancer Research, vol. 63, pp. 7356-7364.
Fox, et al. (1995) cDNA Cloning and Tissue Distribution of Five Human EPH-like Receptor Protein-tyrosine kinases, Oncogene; 10(5): 897-905.
Futami et al. (2002) Induction of Apoptosis in Hela Cells with siRNA Expression Vector Targeted Against BLC-2. Nucleic Acids Research Supplement No. 2:251-2.
Genbank Accession NM 001790 Oct. 10, 2008.
GenBank Accession No. NM—00345, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=6806896. Accessed on Aug. 1, 2008.
Genbank Accession No. NM—002645.2, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=157671928. Accessed on Jul. 31, 2008.
Genbank Accession No. NM—138578, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=20336334. Accessed on Aug. 11, 2008.
Genbank Accession Z15005.1 (1993).
Hammond et al., Post-transcriptional gene silencing by double-stranded RNA, Nature Reviews, 2001, vol. 2, 110-119 ) MacMilan Magazines Ltd.
Hao, et al. (2004) Expression Analysis of the Human Testis-specific Serine/Threonine Kinase (TSSK) Homologues. A TSSK Member is Present in the Equatorial

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

siRNA targeting TIE-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with siRNA targeting TIE-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and siRNA targeting TIE-2 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4088781

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.