Synthesis of core sugar chain structure of asparagine-linked...

Details Synthesis of core sugar chain structure of asparagine-linked... Synthesis of core sugar chain structure of asparagine-linked...

2004-12-24

2009-10-06

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S029100

Reexamination Certificate

active

07598372

ABSTRACT:
It is intended to chemically synthesize the trisaccharide moiety at the reducing end in the core sugar chain structure of an asparagine-linked glycoprotein. By using a highly inexpensive natural polysaccharide having a mannoseβ-1,4-bond as the starting material, a β-1,4-glycoside bond of mannose is formed.

REFERENCES:
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patent: 99-26956 (1999-06-01), None
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W. Gunther et al., “Synthesis of a β-Mannosyl-Chitobiosyl-Asparagine Conjugate—A Central Core Region Unit of theN-Glycoproteins”, Angew. Chem. Int. Ed. Engl., vol. 29, No. 9, pp. 1050-1051, 1990. (English version of Angewandte Chemie, vol. 102, No. 9, pp. 1068-1069, 1990).
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