Inhibitors of integrin α ν β 6

Details Inhibitors of integrin α ν β 6 Inhibitors of integrin α ν β 6

2002-02-21

2009-12-15

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S304000, C514S275000, C514S352000

Reexamination Certificate

active

07632951

ABSTRACT:
Novel biphenyl derivatives of the general formula (I) in which R1, R1′, R1″, R2, R2′, R3and n are as defined in claim 1, their stereoisomers and their physiologically acceptable salts or solvates are novel integrin inhibitors which preferentially inhibit the αvβ6integrin receptor. The novel compounds can be used, in particular, as medicaments.

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Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelia remodeling. Breuss et. al.
NMR studies of Organic polymorphs and solvates—Robin Harris Nov. 2005.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Goodman et al., “Nanomolar small molecule inhibitors for . . . ,” J. Med. Chem., Jan. 31, 2002, pp. 1045-1051, vol. 45, XP002204360, the whole document.

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