Nucleic acids encoding CD40 binding protein

Details Nucleic acids encoding CD40 binding protein Nucleic acids encoding CD40 binding protein

1998-12-30

2009-06-09

Hayes, Robert C (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S252300, C536S023500

Reexamination Certificate

active

07544481

ABSTRACT:
This invention provides a novel purified mammalian protein having the ability to bind the cytoplasmic region or domain of a CD40 receptor and the nucleic acid molecules coding for this protein. Also provided by this invention are antibodies which specifically bind CD40bp. Methods of using the proteins, nucleic acids and antibodies described above are further provided herein.

REFERENCES:
patent: 0 555 880 (1993-08-01), None
patent: 0 585 943 (1994-03-01), None
patent: WO 93/08207 (1993-04-01), None
patent: WO 94/04570 (1994-03-01), None
Rudinger, In “Peptide Hormones” (ed. J. A. Parsons) University Park Press, Baltimore, pp. 1-7, 1976.
Allen et al., “CD40 ligand gene defects responsible for X-linked hyper-1gM syndrome”Science(1993) 259:990-993.
Altschul et al., “Issues in searching molecular sequence databases”Nature Genet. (1994) 6:119-129.
Anderson, “Human gene therapy”Science(1992) 256:808-813.
Armitage et al., “CD40 ligand is a T cell growth factor”Eur. J. Immunol. (1993) 23:2326-2331.
Armitage et al., “Molecular and biological characterization of a murine ligand for CD40”Nature(1992) 357:80-82.
Banchereau et al., “Long-term human B cell lines dependent on interleukin-4 and antibody to CD40”Science(1991) 251:70-72.
Bordignon et al., “Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells”Proc. Natl. Acad. Sci. USA(1989) 86:6748-6752.
Caux et al., “Activation of human dendritic cells through CD40 cross-linking”J. Exp. Med.(1994) 180:1263-1272.
Cheng et al., “Involvement of CRAF1, a relative of TRAF, in CD40 signaling”Science(1995) 267:1494-1498.
Correll et al., “Production of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells”Proc. Natl. Acad. Sci. USA(1989) 868912-8916.
Culver, “Lymphocytes as cellular vehicles for gene therapy in mouse and man”Proc. Natl. Acad. Sci. USA(1991) 88:3155-3159.
Fuleihan et al., “Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM”Proc. Natl. Acad. Sci. USA(1993) 90:2170-2173.
Harper et al., “The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases”Cell(1993) 75:805-816.
Herlyn et al., “Anti-idiotypic antibodies bear the internal image of human tumor antigen”Science(1986) 232:100-102.
Higuchi et al., “A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions”Nucl. Acids Res.(1988) 16:7351-7367.
Hu et al., “A novel RING finger protein interacts with the cytoplasmic domain of the CD40”J. Biol. Chem.(1994) 269:30069-30072.
Inui et al., “Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40”Eur. J. Immunol.(1990) 20:1747-1753.
Korthäuer et al., “Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM”Nature(1993) 361:539-541.
Liu et al., “Mechanism of antigen-driven selection in germinal centres”Nature(1989) 342:929-931.
Lupas et al., “Predicting coiled coils from protein sequences”Science(1991) 252:1162-1164.
Mosialos et al., “The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family”Cell(1995) 80:389-399.
Ochs et al., “Advances in X-linked immunodeficiency diseases”Curr. Opin. Pediatr.(1993) 5:684-691.
Oi et al., “Chimeric antibodies”BioTechniques(1986) 4:214-221.
O'Rourke et al., “Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers”J. Biol. Chem.(1992) 267:24921-24924.
Rill et al., “An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer”Blood(1992) 79:2694-2700.
Ron et al., “pGSTag—a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins”BioTechniques(1992) 13:866-869.
Sato et al., “A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40”FEBS Letters(1995) 358:113-118.
Spira et al., “The identification of monoclonal class switch variants by sib selection and an ELISA assay”J. Immunol. Meth.(1984) 74:307-315.
Stamenkovic et al., “A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas”EMBO J. (1989) 8:1403-1410.
Staudinger et al., “Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system”J. Biol. Chem. (1993) 268:4608-4611.
Studier, “Use of bacteriophage T7 lysozyme to improve an inducible T7 expression system”J. Mol. Biol. (1991) 219:37-44.
Torres et al., “Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation”J. Immunol. (1992) 148:620-626.
Werner-Favre et al., “Similar CD40 ligand expression on EL-4 thymoma cell lines with widely different helper activity for B lymphocytes”Immunol. (1994) 81:111-114.
Yang et al., “A protein kinase substrate identified by the two-hybrid system”Science(1992) 257:680-682.
Zhang et al., “CD40 stimulation provides an IFN-τ-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production”J. Immunol. (1991) 146:1836-1842.
Irie, S., et al., “A Novel cDNA Encoding a Protein that Binds the Cytoplasmic Domain of CD40,”J. Cell. Biochem. (1995) Abstract Supplement 19A:36 (Abstract A1-234).

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