Antagonists of TWEAK and of TWEAK receptor and their use to...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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Reexamination Certificate

active

07579001

ABSTRACT:
The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.

REFERENCES:
patent: 6207642 (2001-03-01), Wiley
patent: 6727225 (2004-04-01), Wiley
patent: 6824773 (2004-11-01), Wiley
patent: 7169387 (2007-01-01), Rennert
patent: 2002/0004041 (2002-01-01), Albert et al.
patent: 2002/0042368 (2002-04-01), Fanslow et al.
patent: 2002/0110853 (2002-08-01), Wiley
patent: 2003/0162712 (2003-08-01), Cerretti et al.
patent: 2003/0170228 (2003-09-01), Ashkenazi et al.
patent: 2003/0198640 (2003-10-01), Yu et al.
patent: 2003/0211096 (2003-11-01), Ashkenazi et al.
patent: 2003/0211993 (2003-11-01), Jakubowski et al.
patent: 2003/0216546 (2003-11-01), Tykocinski
patent: 2004/0014176 (2004-01-01), Ashkenzai et al.
patent: 2004/0018170 (2004-01-01), Shirwan
patent: 2004/0033225 (2004-02-01), Browning et al.
patent: 2004/0047854 (2004-03-01), Black et al.
patent: 2004/0091473 (2004-05-01), DuBose et al.
patent: 2005/0112666 (2005-05-01), Browning et al.
patent: 2005/0118629 (2005-06-01), Browning et al.
patent: WO 98/05783 (1998-02-01), None
patent: WO 98/35061 (1998-10-01), None
patent: WO 98/55508 (1998-12-01), None
patent: WO 99/11791 (1999-03-01), None
patent: WO 99/19490 (1999-04-01), None
patent: WO 99/61471 (1999-12-01), None
patent: WO 00/37638 (2000-06-01), None
patent: WO 01/45730 (2001-06-01), None
patent: WO 01/53486 (2001-07-01), None
patent: WO 03/086311 (2003-10-01), None
Zhao et al. TWEAK/Fn14 Interactions Are Instrumental in the Pathogenesis of Nephritis in the Chronic Graft-versus-Host Model of Systemic Lupus erythematosus. The Journal of Immunology, 2007, 179:7949-7958.
U.S. Appl. No. 09/169,104, filed Oct. 9, 1998, Askenazi et al.
U.S. Appl. No. 09/245,198, filed Feb. 5, 1999, Chicheportiche et al.
Abbas AK et al. “General Properties of Immune Responses”, Introduction to Immunology, pp. 4-12 inCellular and Molecular Immunology, Chapter One, (eds). Philadelphia: WB Saunders Co. (1991).
Abbas AK et al. (eds). “Immunity to Microbes”, pp. 302-314 inCellular and Molecular Immunology, Chapter Fifteen, Philadelphia: WB Saunders Co. (1991).
Ashkenazi and Dixit, “Death Receptors: Signaling and Modulation”, Science, vol. 281, pp. 1305-1308 (1998).
Bach-Elias et al., “Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera”, Parasitol. Res., vol. 84, pp. 196-799 (1998).
Browning et al, “Characterization of surface lymphotoxin forms” J. Immunol, 154:33-46 (1995).
Boucraut et al., “Anti-TWEAK monoclonal antibodies reduces CNS immune cell infiltration and severity of experimental autoimmune encephalomyselitis”, Autoimmunity: Mechanisms and Novel Treatments, Myconos (Greece), Oct. 8-13, 2003, Abstract No. 64.
Cassiano et al. “Molecular Cloning of a Novel Receptor for TWEAK” Scand. J. Immunol. 51 (Supp. 1) 1-111.
Chaplin and Fu, “Current Opinion in Immunology”, vol. 10, pp. 288-297 (1998).
Chicheportiche et al. “Down-regulated expression of TWEAK mRNA in acute and chronic inflammatory Pathologies.” Biochem Biophys Res Commun. Dec. 9, 2000;279(1):162-5.
Chicheportiche et al. “Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies.” Arthritis Res. 2002;4(2):126-33, Epub Nov. 9, 2001.
Chicheportiche et al., “TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family that Weakly Induces Apoptosis”, J. of Biological Chemistry, 272(51): 32401-32410 (1997).
Dallman, “Cytokines and transplantation: Th1/Th2 regulation of the immune response to solid organ transplants in the adult”, Immunology, vol. 7, pp. 632-638 (1995).
Desplat-Jego et al. “Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis”, Clinical Immunology, vol. 117, pp. 15-23 (2005).
Desplat-Jego et al. “Tweak is expressed by glial cells, induces astrocyte proliferation and increases EAE severity. J. Neuroimmunol”, Dec. 2002; 133 (1-2): 116-23.
De Wit et al., “Preferential Activation of Th2 Cells in Chronic Graft-versus-Host Reaction”, The Journal of Immunology, col. 150(2), pp. 361-366 (1993).
Durie et al., “Antibody to the Ligand of CD40, gp39, Blocks the Occurrence of the Acute and Chronic Forms of Graft-vs-Host Disease”, J. Clin. Invest., vol. 94, pp. 1333-1338 (1994).
Flynn et al., “CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1”, J. Exp. Med., vol. 188, pp. 297-304 (1998).
Grewal and Flavell, “The CD40 Ligand”, Immunol. Res., vol. 16, pp. 59-70 (1997).
Grewal and Flavell, “The Role of CD40 Ligand in Costimulation and T-Cell Activation”, Immunol. Rev., vol. 153, pp. 85-106 (1996).
Jakubowski, (2000), Scand. J. Immunol., 51:Sup. 1:62.
Jakubowski, (2002), J. Cell Science, “Dual Role for TWEAK in angiogenic regulation” 115:267-274.
Kalled et al., “Anti-CD40 Ligand Antibody Treatment of SNF1Mice with Established Nephritis: Preservation of Kidney Function”, J. Immunol., vol. 160, pp. 2158-2165 (1998).
Kaplan et al. (1998) J. of Investigative Medicine, vol. 46:287A.
Kornek et al. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J. Pathol. Jul. 2002; 157(1): 267-76.
Krenger and Farrara, “Graft-versus-Host Disease and the Th1/Th2 Paradigm”, Immunol. Res., vol. 15, pp. 50-73 (1996).
Kirk et al., “CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates”, Proc. Natl. Acad. Sci. USA, vol. 94 , pp. 8789-8794 (1997).
Lenchow et al., “Differential Effects of Anti-B7-1 and Anti-B7-2 Monoclonal Antibody Treatment on the Development of Diabetes in the Nonobese Diabetic Mouse”, J. Exp. Med., vol. 181, pp. 1145-1155 (1995).
Lin et al. “Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents” Current Opinion in Chemical Biology, vol. 2, pp. 453-457 (1998).
Lynch et al. “TWEAK induces angiogenesis and proliferation of endothelial cells.” J Biol Chem. Mar. 26, 1999;274(13):8455-9.
Lynch et al., “Tweak Induces Proliferation in Endothelial Cells and Substitutes For EGF and Hydrocortisone in Culture”, Interferon Cytokine Res., vol. 18, A-46 (1998).
Mackay and Browning, “Turning off follicular dendritic cells”, Nature, vol. 395, pp. 26-27 (1998).
Marsters et al., “Identification of a ligand for the death-domain-containing receptor Apo3”, Current Biology, vol. 8, pp. 525-528 (1998).
Meighan-Mantha et al. “The Mitogen-inducible Fn14 Gene Encodes a Type I Transmembrane Protein that Modulates Fibroblast Adhesion and Migration” J. Biol. Chem., Nov. 1999; 274: 33166-33176.
Mohan et al., “Interaction Between CD40 and Its Ligand gp39 in the Development of Murine Lupus Nephritis1”, J. Immunol., vol. 154, pp. 1470-1480 (1995).
Nagata (1997) “Apoptosis by Death Factor” Cell 88:355-365.
Ngo et al., “Computational complexity, protein structure prediction, and the Levinthal paradox”, The Protein Folding Problem, Chapter 14, pp. 435-508 (1994).
Ruuls et al., “The Length of Treatment Determines Whether IFN-β Prevents or Aggravates Experimental Autoimmune Encephalomyelitis in Lewis Rats”,The Journal of Immunology, vol. 157, pp. 5721-5731 (1996).
Steinman, “Optic Neuritis, A New Variant of Experimental Encephalomyelitis, A Durable Model for All Seasons, Now In Its Seventieth Year”The Journal of Experimental Medicine, vol. 197, No. 9, pp. 1065-1071 (2003).
Steinman and Zamvil

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