Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-09-10
2009-02-03
Chunduru, Suryaprabha (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S024310, C536S024320
Reexamination Certificate
active
07485421
ABSTRACT:
Polyamide-oligonucleotide derivatives of the formulain-line-formulae description="In-line Formulae" end="lead"?F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]xF′in-line-formulae description="In-line Formulae" end="tail"?wherein q, r, s, t are, independently of one another, zero or 1, where the total of two or more adjacent q, r, s and t≧2; x is 1 to 20; DNA is a nucleic acid such as DNA or RNA or a known derivative thereof; Li is a covalent linkage between DNA and PNA, where the covalent linkage comprises a bond or an organic radical with at least one atom from the series consisting of C, N, O or S; PNA is a polyamide structure which contains at least one nucleotide base which is different from thymine; and F and F′ are end groups and/or are linked together by a covalent bond, and the physiologically tolerated salts thereof, a process for their preparation and their use as pharmaceutical, as gene probe and as primer, are described.
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Breipohl Gerhard
Uhlmann Eugen
Chunduru Suryaprabha
Hoechst GmbH
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