Synthesis of indenoisoquinolines

Details Synthesis of indenoisoquinolines Synthesis of indenoisoquinolines

2005-05-09

2009-02-24

Davis, Zinna N (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07495100

ABSTRACT:
Indenoisoquinolines and dihydroindenoisoquinolines are described. In particular, such compounds possessing one or more electron withdrawing substituents are described. The in vitro anticancer activities of these molecules tested in the National Cancer Institute's screen of 55 cell lines is described. The compounds tested for topoisomerase I (top1) inhibition is described.

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