Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-08
2009-12-29
Morris, Patricia L (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S256000
Reexamination Certificate
active
07638537
ABSTRACT:
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
REFERENCES:
patent: 4925857 (1990-05-01), Bailey et al.
patent: 6958354 (2005-10-01), Munchhof et al.
patent: 7030125 (2006-04-01), Munchhof et al.
patent: 7053095 (2006-05-01), Munchhof et al.
patent: 2004/0106608 (2004-06-01), Munchhof et al.
patent: 2004/0110797 (2004-06-01), Munchhof et al.
patent: 2004/0176390 (2004-09-01), Blumberg et al.
patent: 2006/0025451 (2006-02-01), Munchhof et al.
patent: 0388691 (1990-09-01), None
patent: 1382603 (2004-01-01), None
patent: WO 98/52937 (1998-11-01), None
patent: WO 98/52941 (1998-11-01), None
patent: WO 00/31063 (2000-06-01), None
patent: WO 00/61576 (2000-10-01), None
patent: WO 01/62756 (2001-08-01), None
patent: WO 01/72737 (2001-10-01), None
patent: WO 02/16359 (2002-02-01), None
patent: WO 02/40468 (2002-05-01), None
patent: WO 02/40476 (2002-05-01), None
patent: WO 02/055077 (2002-07-01), None
patent: WO 02/62787 (2002-08-01), None
patent: WO 02/62794 (2002-08-01), None
patent: WO 02/66462 (2002-08-01), None
patent: WO 02/088107 (2002-11-01), None
patent: WO 03/087304 (2003-10-01), None
patent: WO 2004/013135 (2004-02-01), None
Vippagunta et al., “Crystalline Solid”, Advanced Drug Delivery Reviews 48 (2001) 3-26.
Guillory (in Brtittain ed)., “Polymorphism, etc.,” NY: Marcel Dekker, Inc., 1999, 1-2, 183-226.
Singh et al., “Successful Shape-Based Virtual Screening: The Discovery of a Potent Inhibitor of the Type I TGFbeta Receptor Kinase (TbetaRI)”, Bioorganic & Medicinal Chemistry Letters, vol. 13, No. 24, 2003, pp. 4355-4359.
Database Caplus ′Online! Beilstein Institut zur Foerderung der Chemischen Wissenschaften, Frankfurt am Main, DE; Database accession No. 1220267, XP-002262347, 2,2′-(4-phenyl-1H-pyrazole-3,5-diyl)-bis-pyridine, abstract.
Database Caplus ′Online! Bellstein Institut zur Foerderung der Chemischen Wissenschaften, Frankfurt am Main, DE; Database accession No. 1181440, XP-002262348, 2,2′-[1-(3-methyl-2-phenyl-aziridin-2-yl)-4-phenyl-1H-pyrazole-3,5-diyl]-bis-pyridine, abstract.
Database Caplus ′Online! Chemical Abstracts Service, accession No. 1993:472619, Database accession No. 119:72619, XP-002262349, Preparation of pyrazole and 4H-pyrazolo[1,5-a]pyrimidin-5-one derivatives as antiinflammatory, antirheumatic, antibacterial, and antiviral agents, abstract.
Database Caplus ′Online! Chemical Abstracts Service, accession No. 2000:881141, Database accession No. 134:29414, XP-002262350, Preparation of substituted pyrazole compounds as p38 MAP kinase inhibitors, abstract.
Database Caplus ′Online! Chemical Abstracts Service, accession No. 1996:607249, Database accession No. 125:247806, XP-002262351, Preparation of pyrazole derivatives as antiviral agents, abstract.
PCT International Search Report from PCT/IB03/03933, mailed Mar. 2, 2004.
Sloan et al., “Comparison of the effects of single doses of morphine and thebaine on body temperature, activity, and brain and heart levels of catechol amines and serotonin”, cited in Chem Abstracts, AN 1964:19085, 2002.
Blumberg Laura C.
Munchhof Michael J.
Engelmann John H.
Morris Patricia L
Pfizer Inc.
Pfizer Products Inc.
Yang Lucy X.
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