Collagen-binding molecules that selectively home to tumor...

Details Collagen-binding molecules that selectively home to tumor... Collagen-binding molecules that selectively home to tumor...

2003-08-25

2009-02-10

Helms, Larry R. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C530S328000, C530S327000, C530S326000

Reexamination Certificate

active

07488792

ABSTRACT:
The present invention provides a conjugate containing a therapeutic agent linked to a homing molecule that selectively homes to tumor vasculature and selectively binds collagen such as non-helical collagen or collagen IV. In one embodiment, the conjugate contains a homing peptide or peptidomimetic that includes the amino acid sequence CREKA (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof.

REFERENCES:
patent: 5320970 (1994-06-01), Eyre et al.
patent: 5541295 (1996-07-01), Barrach et al.
patent: 5622699 (1997-04-01), Ruoslahti et al.
patent: 5763272 (1998-06-01), Naser et al.
patent: 5874399 (1999-02-01), Samal
patent: 6030792 (2000-02-01), Otterness et al.
patent: 6132976 (2000-10-01), Poole et al.
patent: 6491894 (2002-12-01), Ruoslahti et al.
patent: 2003/0113331 (2003-06-01), Brooks et al.
patent: 2004/0091482 (2004-05-01), Watkins et al.
patent: 0 510 949 (1992-10-01), None
patent: 0 921 395 (1998-12-01), None
patent: WO 94/14070 (1994-06-01), None
patent: WO 95/04282 (1995-02-01), None
patent: WO 97/44059 (1997-11-01), None
patent: WO 98/10795 (1998-03-01), None
patent: WO 98/35235 (1998-08-01), None
patent: WO 99/06840 (1999-02-01), None
patent: WO 99/13329 (1999-03-01), None
patent: WO 99/46284 (1999-09-01), None
patent: WO 00/40597 (2000-07-01), None
Mathews and Van Holde, Biochemistry, 1996, pp. 165-171.
W. Burgess, AShaheen, et al., Activities of Heparin-binding (Acidic Fibroblast) Growth Factor-1 from its Receptor-binding Activities by Site-directed Mutagenesis of a Single Lysine Residue. The Journal of Cell Biology. Vo. 111, 1990, 2129-2138.
Lazar et al., Molecular and Cellular Biology, vol. 8, p. 1247-1252, 1988.
Simth et al., (Chem Rev, vol. 97, pp. 391-410).
Antman, “Randomized Trials of High Dose Chemotherapy for Breast Cancer,”Biochimica et Biophysica Acta1471:M89-M98 (2001).
Arap et al., “Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model,”Science279:377-380 (1998).
Borgstrom et al., “Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin,”Anticancer Res. 19:4203-4214 (1999).
Brown et al., “A novel approach for the identification of unique tumor vasculature binding peptides using anE. colipeptide display library,”Ann. Surg. Oncol. 7:743-749 (2000).
Burris III, “Docetaxel (Taxotere) Plus Trastuzumab (Herceptin) in Breast Cancer,”Semin. Oncol. 28 (suppl 3) :38-44 (2001).
Carnemolla et al., “Enhancement of the antitumor propeties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix,”Blood99:1659-1665 (2002).
Chan et al., “Prospective Randomized Trial of Docetaxel Versus Doxorubicin in Patients with Metastatic Breast Cancer,”J. Clin. Oncol. 17:2341-2354 (1999).
Chen et al., “RGD-Tachyplesin Inhibits Tumor Growth,”Cancer Res. 61:2434-2438 (2001).
Crown, “The Platinum Agents: A Role in Breast Cancer Treatment?,”Semin. Oncol. 28 (suppl 3) :28-37 (2001).
Curnis et al., “Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptides N (CD 13),”Nature Biotech. 18:1185-1190 (2000).
Dogic et al., “Extracellular matrix, integrins and focal adhesions,”Curr. Topics Pathol. 93:75-83 (1999).
Ellerby et al., “Anti-cancer activity of targeted pro-apoptotic peptides,”Nat. Med. 5:1032-1038 (1999).
Engvall et al., “Nonhelical, fibronectin-binding basement-membrane collagen from endodermal cell culture,”Cell29:475-482 (1982).
Essler and Ruoslahti, “Molecular specialization of breast vasculature: A breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature,”Proc. Natl. Acad. Sci. USA99:2252-2257 (2002).
Fisher et al., “Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study,”J. Natl. Cancer Instit. 90:1371-1388 (1998).
Harris et al., “Cancer of the Breast”,Cancer: Principles and Practice of Oncology, 4th Edition, Chapter 40, DeVita, Jr. et al., J.P. Lippincott: Philadelphia (1993).
Herbst et al., “Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migration,”J. Cell Biol. 106:1365-1373 (1988).
Hood et al., “Tumor regression by targeted gene delivery to the neovasculature,”Science296:2904-2407 (2002).
Hoppe and Reid, “Collectins—soluble proteins containing collagenous regions and lectin domains—and their roles in innate immunity,”Protein. Sci. 3:1143-1158 (1994).
Jenkins and Raines, “Insights on the conformational stability of collagen,”Nat. Prod. Rep. 19:49-59 (2002).
Kennel et al., “Labeling and distribution of linear peptides identified using in vivo phage-display selection for tumors,”Nuc. Med. Biol. 27 :815-825 (2000).
Koivunen et al., “Tumor Targeting with a Selective Gelatinase Inhibitor,”Nat. Biotechnol. 17:768-774 (1999).
Kühn, “Basement membrane (Type IV) collagen,”Matrix Biology14:439-445 (1994).
Laakkonen et al., “A tumor-homing peptide with a targeting specificity related to lymphatic vessels,”Nature Med. 8:751-755 (2002).
Marneros and Olsen, “The role of collagen-derived proteolytic fragments in angiogenesis,”Matrix Biology20:337-345 (2001).
Myllyharju and Kivirikko, “Collagens and collagen-related diseases,”Ann. Med. 33:7 (2001).
Oku et al., “Anti-neo-vascular therapy using novel peptides homing to angiogenic vessels,”Oncogene21:2662-2669 (2002).
Paridaens et al., “Paclitsxel Versus Doxorubicin as First-Line Single-Agent Chemotherapy for Metastatic Breast Cancer: a European Organization for Research and Treatment of Cancer Randomized Study with Cross-over,”J. Clin. Oncol. 18:724-733 (2000).
Pasqualini and Ruoslahti, “Organ Targeting in Vivo Using Phage Display Peptide Libraries,”Nature380:364-366 (1996).
Porkka et al., “A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo,”Proc. Natl. Acad. Sci. USA99:7444-7449 (2002).
Rajotte et al., “Molecular Heterogeneity of the Vascular Endothelium Revealed by in Vivo Phage Display,”J. Clin. Invest. 102:430-437 (1998).
Rasmussen et al., “Tumor cell targeting by phage-displayed peptides,”Cancer Gene Ther. 9:606-612 (2002).
Ritter et al., “Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis,”Proc. Natl. Acad. Sci. USA99:7455-7460 (2002).
Ruoslahti and Rajotte, “An address system in the vasculature of normal tissues and tumors,”Annu. Rev. Immunol. 18:813-827 (2000).
Sado et al., “Organization and expression of basement membrane collagen IV genes and their roles in human disorders,”J. Biochem. 123:767-776 (1998).
Sidhu et al., “Phage display for selection of novel binding peptides,”Methods Enzym. 328:333-363 (2000).
Sipkins et al., “Detection of tumor angiogenesis in vivo by αVβ3-targeted magnetic resonance imaging,”Nature Med. 4 :623-626 (1998).
Timpl and Brown, “Supramolecular assembly of basement membranes,”Bioessays18:123-132 (1996).
Timpl et al., “Macromolecular organization of basement membranes,”Curr. Opin. Cell Biol. 8:618-624 (1996).
Tsai, “Stuck on the ECM,”Trends Cell Biol. 8:292-295 (1998).
Vicini et al., “Accelerated Treatment of Breast Cancer,”Journal of Clinical Oncology19:1993-2001 (2001).
White et al., “Antibody-Targeted Immunotherapy for Treatment of Malignancy,”Annu. Rev. Med. 52:125-145 (2001).
Wolff, “Systemic Therapy,”C

Affiliated with

Also associated with

Rating

Collagen-binding molecules that selectively home to tumor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Collagen-binding molecules that selectively home to tumor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Collagen-binding molecules that selectively home to tumor... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4079111