Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-10-16
1989-06-06
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142352, 514253, 514322, 514323, 514381, 514406, 514414, 514419, 514415, 544140, 544143, 544144, 544371, 544373, 546199, 546201, 548253, 548371, 548372, 548405, 548468, 548494, 548505, 548506, 548507, 548510, A61K 31535, C07D23156
Patent
active
048372358
ABSTRACT:
This invention provides a series of novel keto sulfones of formula I ##STR1## in which the group .dbd.A-- is selected from .dbd.C(Ra)-- and .dbd.N-- and the other radicals have the meanings defined in the following specification.
The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
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Hannig, E., et al., Pharmazie 29, H. 10-11 (1974), pp. 685-686.
Krell, Robert D., The Journal of Pharmacology and Experimental Therapeutics, vol. 211, No. 2, pp. 436-443 (1979).
Marx, Jean L., Science, vol. 215, Mar. 12, 1982, pp. 1380-1382.
Denzlinger, C., et al., Science, vol. 230, pp. 330-332 (1985).
Cook, J. A., et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 235, No. 2, pp. 470-474 (1985).
Bernstein Peter R.
Brown Frederick J.
Matassa Victor G.
Yee Ying K.
ICI Americas Inc.
Jackson Thomas E.
Miano Rosemary M.
Schwartz Richard A.
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