Polymorphic markers of prostate carcinoma tumor antigen...

Details Polymorphic markers of prostate carcinoma tumor antigen... Polymorphic markers of prostate carcinoma tumor antigen...

2004-05-27

2009-06-16

Switzer, Juliet C (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023400, C536S024300, C536S024310

Reexamination Certificate

active

07547771

ABSTRACT:
The invention concerns the geNo.mic sequence and cDNA sequences of the PCTA-1 gene. The invention also concerns biallelic markers of the PCTA-1 gene and the association established between these markers and prostate cancer. The invention provides means to determine the predisposition of individuals to prostate cancer as well as means for the diagNo.sis of prostate cancer and for the progNo.sis/detection of an eventual treatment response to agents acting against prostate cancer.

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GenBank Accession No. CU459202, Oct. 9, 2007.
Entrez Gene Entry for LGALS8, alias PCTA-1, GeneID: 3964, updated Oct. 21, 2007, URL: http://www.ncbi.nlm.nih.gov/sites/entrez.
Su, Z. Z. et al. “Surface-epitope Masking and Expression Cloning Identifies the Human Prostate Carcinoma Tumor Antigen Gene PCTA-1 a Member of the Galectin Gene Family”,Proc. Natl. Acad. Sci. USA, Jul. 1996, pp. 7252-7257, vol. 92.
Syvanen, A. C. et al. “Identification of Individuals by Analysis of Biallelic DNA Markers, Using PCR and Solid-phase Minisequencing”,Am. J. Hum. Genet, Jan. 1993, pp. 46-59, vol. 52, No. 1.
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Berthon, et al. “Predisposing Gene for Early-Onset Prostate Cancer, Localized on Chromosome 1q42.2-43”,Am. J. Hum Genet., 1998, pp. 1416-1424, vol. 62.
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