Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reissue Patent
2003-06-09
2009-12-01
Duffy, Patricia A (Department: 1645)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reissue Patent
active
RE041028
ABSTRACT:
Intestinal trefoil factors and nucleic acids encoding intestinal trefoil factors are disclosed. The intestinal trefoil factors disclosed are resistant to destruction in the digestive tract and can be used for the treatment of peptic ulcer diseases, inflammatory bowel diseases, eye disorders and other insults.
REFERENCES:
patent: 4370317 (1983-01-01), Jorgensen et al.
patent: 5541210 (1996-07-01), Cupps et al.
patent: 5703047 (1997-12-01), Wilson
patent: 5783416 (1998-07-01), Thim et al.
patent: 5830706 (1998-11-01), Mascarenhas et al.
patent: 5843701 (1998-12-01), Gold et al.
patent: 6063755 (2000-05-01), Podolsky
patent: 6221840 (2001-04-01), Podolsky
patent: 6288118 (2001-09-01), Nieman et al.
patent: 6316218 (2001-11-01), Podolsky
patent: 6426404 (2002-07-01), Podolsky
patent: 6525018 (2003-02-01), Podolsky
patent: 6685917 (2004-02-01), Rosenthal et al.
patent: 6984628 (2006-01-01), Bakhit et al.
patent: 2002/0052483 (2002-05-01), Podolsky
patent: 2002/0119104 (2002-08-01), Rosenthal et al.
patent: 2002/0151472 (2002-10-01), Thim et al.
patent: 2002/0187487 (2002-12-01), Goldenring et al.
patent: 2003/0032585 (2003-02-01), Thim et al.
patent: 2003/0077696 (2003-04-01), Thim et al.
patent: 2003/0078205 (2003-04-01), Podolsky
patent: 2003/0105016 (2003-06-01), Podolsky
patent: 2003/0114384 (2003-06-01), Podolsky
patent: 2003/0134797 (2003-07-01), Podolsky
patent: 2003/0148949 (2003-08-01), Podolsky
patent: 2003/0153496 (2003-08-01), Thim et al.
patent: 2003/0166535 (2003-09-01), Podolsky
patent: 2003/0181383 (2003-09-01), Podolsky
patent: 2003/0181384 (2003-09-01), Podolsky
patent: 2003/0185838 (2003-10-01), Podolsky
patent: 2003/0185839 (2003-10-01), Podolsky
patent: 2003/0186880 (2003-10-01), Podolsky
patent: 2003/0186882 (2003-10-01), Podolsky
patent: 2003/0186886 (2003-10-01), Podolsky
patent: 2003/0215431 (2003-11-01), Thim et al.
patent: 2003/0225250 (2003-12-01), Podolsky
patent: 2004/0171544 (2004-09-01), Barker et al.
patent: 2005/0287640 (2005-12-01), Thim et al.
patent: 2006/0019881 (2006-01-01), Thim et al.
patent: 2006/0046958 (2006-03-01), Bakhit et al.
patent: 2006/0111278 (2006-05-01), Thim et al.
patent: 2006/0188471 (2006-08-01), Podolsky
patent: 2006/0189526 (2006-08-01), Podolsky
patent: 2006/0211605 (2006-09-01), Thimm et al.
patent: 2006/0241037 (2006-10-01), Olejnik et al.
patent: 2006/0293221 (2006-12-01), Thim et al.
patent: 2007/0062517 (2007-05-01), Barker
patent: 2007/0148733 (2007-07-01), Woon et al.
patent: 0 534 310 (1993-03-01), None
patent: 2769502 (1999-04-01), None
patent: WO 86/02271 (1986-04-01), None
patent: WO 92/14837 (1992-09-01), None
patent: WO 94/17102 (1994-08-01), None
patent: WO 96/06861 (1996-03-01), None
patent: WO 97/38712 (1997-10-01), None
patent: WO 98/30592 (1998-07-01), None
patent: WO 99/18927 (1999-04-01), None
patent: WO 00/20868 (2000-04-01), None
patent: WO 00/074655 (2000-12-01), None
patent: WO 01/02570 (2001-01-01), None
patent: WO 01/29269 (2001-04-01), None
patent: WO 02/46226 (2002-06-01), None
patent: WO 02/085402 (2002-10-01), None
patent: WO 02/102399 (2002-12-01), None
patent: WO 02/102403 (2002-12-01), None
patent: WO 03/068817 (2003-08-01), None
patent: WO 2004/064860 (2004-08-01), None
patent: WO 2005/009459 (2005-02-01), None
patent: WO 2005/039619 (2005-05-01), None
patent: WO 2005/039640 (2005-05-01), None
Richter et al, J. Biol. Chem. 270(4):1612-1616, 1995.
Harmer et al, Biochemistry, 43(3):629-640, 2004.
Bare et al, Biochemical and Biophysical Research Communications, 205(1):877-879, 1994.
Wbsters Dictionary—definition trefoil, 1998.
MSN Encarta Dictionary—definition for trefoil, 2006.
Blast alignment of human and rat ITF, currently know as Trefoil factor 3 (TTF3), 2 pages, 2007.
Alderman et al., “Insights into the mechanisms of gastric adaption to aspirin-induced injury: A role for regenerating protein but not trefoil peptides,”Laboratory Investigation83:1415-1425 (2003).
Hanby et al., “Expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hsp) in barrett's metaplasia and the native esophageal epithelium: delineation of epithelial phenotype,”J. of Pathology173:213-219 (1994).
Hauser et al., “hP1.B5 A human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus,”Proc. Natl. Acad. Sci.90:6961-6965 (1993).
Hawkey et al., “Gastrointestinal safety of AZD3582, a cyclooxygenase inhibiting nitric oxide donator: proof of concept study in humans,”Gut52:1537-1542 (2003).
Muskett et al., “Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): The intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins,”Biochemistry42:15139-15147 (2003).
Poulsom et al., “Trefoil peptides: a newly recognized family of epithelial mucin-associated molecules,”Am. J. Physiol.265:G205-213 (1993).
Thim, “Trefoil peptides: A new family of gastrointestinal molecules,” Digestion 55:353-360 (1994).
Van de Bovenkamp et al, “Gastric-type mucin and TFF-peptide expression in Barrett's oesophagus is disturbed during increased expression of MUC2,”Histopathology42:555-565 (2003).
Williams et al., “pS2 transfection of murine adenocarcinoma cell line 410.4 enhances dispersed growth pattern in a 3-D collagen gel,”J. Cell Sci.109:63-71 (1996).
Zhang, “The therapeutic effect of recombinant human trefoil factor 3 on hypoxia-induced necrotizing enterocolitis in immature rat,”Regulatory Peptides116:53-60 (2003).
Attwood et al.,Science290:471-473 (2000).
Babyatsky et al., “Trefoil peptides protect against ethanol and indomethacin induced gastric injury in rats”Gastroenterology106: A43 (1994).
Burling et al.,American Journal of Veterinary Research61:1150-1155 (2000).
Dignass et al., “Trefoil peptides promote epithelial migration through a transforming growth factor β-independent pathway”J. Clin. Invest.94:376-383 (1994).
Falk et al., “Expression of a human α-1/,3/4-Fucosyltransferase in the pit cell linease of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying He licobacter pylori infection”Proc. Natl. Sci. USA92:1515-1519 (1995).
Gerhold et al.,BioEssays18:973-981 (1996).
Jakowlew et al., “Sequence of the pS2 mRNA induced by estrogen in the human breast cell line MCF-7”Nucleic Acid Res .12:2861-2878 (1994).
Jeffrey et al., “Spasmolytic-polypeptide: A trefoil peptide secreted by rat gastric mucous cells”Gastroenterology106:336-345 (1994).
Jorgensen et al., “Pancreatic spasmolytic polypeptide (PSP): III. Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects”Regulatory Peptides3:231-243 (1982).
Modlin et al., “Trefoil peptides: mitogens, motogens, or mirages?”J. Clin. Gastroenterol.25(Supp. 1): S94-S100 (1997).
Mori et al., “Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product”Biochem. Biophys. Res. Comm.155:366 (1988).
Okayasu et al., “A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice”Gastroenterology98:694-702 (1990).
Podolsky et al., “Demonstration of distinct subpopulations defined by mucin-specific monoclonal antibodies”J. Clin. Invest.77:1263-1271 (1986).
Podolsky et al., “Identification of human intestinal trefoil factor”J. Biol. Chem.268:6698-6702 (1993).
Podolsky et al., “Latent transformed growth-inhibiting factor in human malignant effusions”,Cancer Res.48:418-424 (1988).
Russell et al.,J. Mol. Biol.244:332-350 (1994).
Sands et al., “The trefoil peptide family”Ann. Rev. of Physiol.58:253-273 (1996).
Suemori et al., “Identification and characterizat
Clark & Elbing LLP
Duffy Patricia A
The General Hospital Corporation
LandOfFree
Treating eye disorders intestinal trefoil proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treating eye disorders intestinal trefoil proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treating eye disorders intestinal trefoil proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4072120