Process for the preparation of halogenated aliphatic ethers

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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568683, C07C 4101

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active

043650970

ABSTRACT:
Processes for the preparation of certain halogenated aliphatic ethers are described, and in particular the preparation of 1,1,2-trifluoro-2-chloroethyl methyl ether, i.e., CH.sub.3 OCF.sub.2 CHFCl. This particular ether has many uses, and is a valuable material for use in the production of the inhalant anesthetic enflurane, 1,1,2-trifluoro-2-chloroethyl difluoromethyl ether, i.e., CF.sub.2 HOCF.sub.2 CHFCl, made and sold under the trademark ETHRANE by Airco, Inc., Montvale, New Jersey 07645.

REFERENCES:
patent: 2332467 (1943-10-01), Linn et al.
patent: 3931238 (1976-01-01), Starks
Freedman et al., Tetrahedron Letters, No. 38, pp. 3251-3254, 1975.
Herreott et al., Tetrahedron Letters, No. 44, pp. 4521-4524, 1972.
Corley et al., J. Am. Chem. Soc., 78, pp. 3489-3492, 1956.
Scipioni et al., Translation Ann. Chim. Rome, 1967, 57(7), 817-824.

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