Methods to facilitate transmission of large molecules across...

Details Methods to facilitate transmission of large molecules across... Methods to facilitate transmission of large molecules across...

2006-11-17

2009-12-08

Stucker, Jeffrey (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S145100, C424S134100, C424S085100, C424S001410, C424S001490, C435S335000

Reexamination Certificate

active

07629311

ABSTRACT:
A method for delivering a biologic to a human with Alzheimer's-related dementia, comprising administering the biologic parenterally into the perispinal space of the human without direct intrathecal injection, and thereafter positioning the human's head below the horizontal. The method further includes delivering a TNF antagonist to the brain of a human for treating mild cognitive impairment, Alzheimer's related dementia, or vascular dementia, comprising administering the TNF antagonist golimumab parenterally into the perispinal space of the human without direct intrathecal injection, and thereafter positioning the human in a Trendelenburg position, for delivery of the golimumab to the brain via the human's vertebral venous system.

REFERENCES:
Tobinick and Gross, J Neuroinflam 5: 1-10, 2008.
W Sue T Griffin J Neuroinflamm 5: 1-3, 2008.

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