Pharmaceutical preparations and medicines capable of...

Details Pharmaceutical preparations and medicines capable of... Pharmaceutical preparations and medicines capable of...

2005-01-21

2009-02-24

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C435S214000, C530S381000

Reexamination Certificate

active

07494971

ABSTRACT:
The invention relates to a pharmaceutical active ingredient preparation for producing a medicament that contains thrombin or has a thrombin-generating capacity and compositions comprising thereof. The inventive preparation contains: (A) prothrombin obtained from plasma or by means of genetic engineering (coagulation factor II), (B) coagulation factors V, VIII, IX, X obtained from plasma or by means of genetic engineering, which can be at least partially in the activated state, and coagulation factor Xla obtained from plasma or by means of genetic engineering, and (C) phospholipids which are safe from prions and contribute to the clotting process, said phospholipids being optionally contained in liposomes.

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Search Report for PCT/AT2003/000208 (translation).
Butenas et al., “Normal” Thrombin Generation, Blood, 1999, 94:2169-2178.
Lämmle and Griffin, 1985, “Formation of the fibrin clot: the balance of procoagulant and inhibitory factors,” Clinics in Haematology 14(2):281-342.

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