Substituted pyrazolo[1,5-a]pyrimidines as protein kinase...

Details Substituted pyrazolo[1,5-a]pyrimidines as protein kinase... Substituted pyrazolo[1,5-a]pyrimidines as protein kinase...

2006-10-04

2009-10-13

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S281000

Reexamination Certificate

active

07601724

ABSTRACT:
In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. An illustrative compound of the invention is shown below:

REFERENCES:
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
Vippagunta et. al., Advanced Drug Delivery, 2001,, 48, 3-26.

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