Process for preparing 2-oxindole-1-carboxamides

Details Process for preparing 2-oxindole-1-carboxamides Process for preparing 2-oxindole-1-carboxamides

1994-01-28

1995-09-12

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548431, 548450, 548467, 548468, C07D20934

Patent

active

054497884

ABSTRACT:
The present invention provides a process for preparing 2-oxindole-1-carboxamides, comprising reacting N-acyl 2-oxindole-1-carboxamides with alcohols in the presence of aprotic weak Lewis acid catalysts. In certain processes of the present invention a 2-oxindole-1-carboxamide is prepared from a 2-oxindole by reacting the 2-oxindole with an acyl isocyanate to produce the N-acyl 2-oxindole-1-carboxamide as an intermediate, which is then reacted with alcohol in the presence of aprotic weak Lewis acid catalysts. The N-acyl 2-oxindole-1-carboxamide intermediate may be converted to the 2-oxindole-1-carboxamide without isolation.

REFERENCES:
patent: 3634453 (1972-01-01), McManus et al.
patent: 3965095 (1976-06-01), Seemann
patent: 4145422 (1979-03-01), Winn et al.
patent: 4176191 (1979-11-01), Winn et al.
patent: 4209625 (1980-06-01), Ong et al.
patent: 4556672 (1985-12-01), Kadin
patent: 4569942 (1986-02-01), Kadin
patent: 4652658 (1987-03-01), Crawford
patent: 4665194 (1987-05-01), Crawford
patent: 4686224 (1987-08-01), Melvin, Jr.
patent: 4725616 (1988-02-01), Kadin
patent: 4791129 (1988-12-01), Kadin
patent: 4952703 (1990-08-01), Kelly
patent: 4960785 (1990-10-01), Howard, Jr. et al.
patent: 5086186 (1992-02-01), Kelly
patent: 5374652 (1994-12-01), Buzzetti et al.
R. Graf, "Reactions with N-Carbonylsulfamoyl Chloride," Angew. Chem. Internat., Edit 1, vol. 7, pp. 172-182 (1968).

Affiliated with

Also associated with

Rating

Process for preparing 2-oxindole-1-carboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing 2-oxindole-1-carboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing 2-oxindole-1-carboxamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-406315