Inhibitors of plasma kallikrein

Details Inhibitors of plasma kallikrein Inhibitors of plasma kallikrein

2007-07-30

2009-12-01

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S443000, C514S419000, C514S471000, C514S448000, C514S423000, C514S406000, C514S365000, C514S343000, C514S336000, C546S280400, C546S279100, C548S537000, C548S374100, C548S255000, C548S200000, C548S492000, C549S057000, C549S468000, C549S070000, C549S483000

Reexamination Certificate

active

07625944

ABSTRACT:
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease or condition, for example, after fibrinolysis treatment.

REFERENCES:
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patent: 6337344 (2002-01-01), Defossa et al.
patent: WO 9928297 (1999-06-01), None
patent: WO 2008/016883 (2008-07-01), None
Govers-Riemslag et al. Journal of Thrombosis and Haemostasis 2007, 5, 1896-903.
Phipps et al. Kidney International 2008, 73, 1114-9.
A.H. Schmaier J. Clin. Invest. 2002, 109, 1007-9.
International Search Report mailed on Feb. 6, 2008, for PCT Application No. PCT/US07/74761 filed on Jul. 30, 2007, 3 pages.

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