Chimeric, human and humanized anti-CSAp monoclonal antibodies

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S133100, C424S136100, C424S138100, C424S156100, C435S069600, C435S069700

Reexamination Certificate

active

07553953

ABSTRACT:
The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers, including colon cancer.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4468457 (1984-08-01), Goldenberg et al.
patent: 4735210 (1988-04-01), Goldenberg
patent: 4737453 (1988-04-01), Primus
patent: 4792521 (1988-12-01), Shochat
patent: 4818709 (1989-04-01), Primus
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4971792 (1990-11-01), Stephewski et al.
patent: 5078998 (1992-01-01), Bevan et al.
patent: 5101827 (1992-04-01), Goldenberg
patent: 5128119 (1992-07-01), Griffiths
patent: 5183756 (1993-02-01), Schlom
patent: 5225541 (1993-07-01), Hackett et al.
patent: 5274076 (1993-12-01), Barbet et al.
patent: 5328679 (1994-07-01), Hansen et al.
patent: 5469854 (1995-11-01), Unger et al.
patent: 5502037 (1996-03-01), Kondratyer
patent: 5503987 (1996-04-01), Wagner
patent: 5534254 (1996-07-01), Huston
patent: 5535254 (1996-07-01), Huston et al.
patent: 5591828 (1997-01-01), Bosslet et al.
patent: 5683694 (1997-11-01), Bagshawe et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 5697902 (1997-12-01), Goldenberg
patent: 5716595 (1998-02-01), Goldenberg
patent: 5746996 (1998-05-01), Govindan et al.
patent: 5753206 (1998-05-01), McBride et al.
patent: 5772981 (1998-06-01), Govindan et al.
patent: 5776093 (1998-07-01), Goldenberg
patent: 5776094 (1998-07-01), Goldenberg
patent: 5776095 (1998-07-01), Goldenberg
patent: 5837242 (1998-11-01), Holliger et al.
patent: 5837243 (1998-11-01), Deo et al.
patent: 5851527 (1998-12-01), Hansen
patent: 5959083 (1999-09-01), Bosslet et al.
patent: 6010680 (2000-01-01), Govindan et al.
patent: 6077499 (2000-06-01), Griffiths et al.
patent: 6096289 (2000-08-01), Goldenberg
patent: 6121424 (2000-09-01), Whitlow et al.
patent: 6126916 (2000-10-01), McBride
patent: 6187284 (2001-02-01), Griffiths
patent: 6962702 (2005-11-01), Hansen
patent: 7074405 (2006-07-01), Hansen
patent: 7091321 (2006-08-01), Gillies et al.
patent: 7387772 (2008-06-01), Hansen et al.
patent: 7414121 (2008-08-01), Hansen et al.
patent: 2002/0006379 (2002-01-01), Hansen et al.
patent: 0263046 (1988-04-01), None
patent: 0511011 (1992-10-01), None
patent: 0517024 (1992-12-01), None
patent: 0623675 (1994-11-01), None
patent: 921782 (1992-12-01), None
patent: 03173900 (1991-07-01), None
patent: 9604313 (1996-02-01), None
patent: 9741898 (1997-11-01), None
patent: 9808875 (1998-03-01), None
patent: 9966951 (1999-12-01), None
patent: 00/34317 (2000-06-01), None
Krishnan et al, Suppl. to Cancer, vol. 80, 2667-2674, 1997.
McGuinness et al. Phage diabody repertoires for selection of large numbers of bispecific antibody fragments, Nature Biotechnology. 14:1149-1154 (1996).
Olafsen et al., “1gM secretory tailpiece drives multimerisation of bivalent scFv fragments in eukaryotic cells,” Immunotechnology, 4(2):141-153 (1998).
Kipriyanov et al. “Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics,” J. Mol. Biol., 293(1):41-56 (1999).
Karacay et al., “Studies on a humanized anti-CEA x murine anti-(In-DTPA) bispecific antibody construct for radioimmunotherapy of CEA-positive tumors,” Proceedings of the American Association for Cancer Research Annual Meeting, vol. 40, p. 644, (Mar. 1999).
Karacay et al., “Pretargeting studies with a humanized anti-CEAX murine anti-(In- DTPA) bispecific antibody construct and Tc-99m/Re-188 labeled peptide,” Journal of Nuclear Medicine, vol. 40, No. 5 Suppl.,p. 225 (May 1999).
Gautherot et al., “Delivery of therapeutic doses of radioiodine using bispecific antibody—targeted bivalent haptens,” Journal of Nuclear Medicine, vol. 39 (11), pp. 1937-43 (Nov. 1998).
Bodere et al. “Phase I/II total of two-step radioimmunotherapy in medullary thyroid cancer (MTC) using bispecific anti-CEA/anti- DTPA—in antibody and iodine-131-labeled bivalent hapten,” Journal of Nuclear Medicine, vol. 39, No. 5 Suppl, p. 246 (May 1998).
Bardies et al., “Bispecific antibody and iodine-131-labeled bivalent hapten dosimetry in patients with medullary thyroid or small-cell lung cancer,” Journal of Nuclear Medicine, vol. 37, pp. 1853-1859 (Nov. 1996).
Hosono et al., “Biodistribution and dosimetric study in medullary thyroid cancer xenograft using bispecific antibody and iodine-125-labeled bivalent hapten.” Journal of Nuclear Medicine, vol. 39 (9), pp. 1608-13 (Sep. 1998).
Kranenborg et al., “Development and characterization of and-renal cell carcinoma x antichelate bispecific monoclonal antibodies for two-phase targeting of renal cell carcinoma,” Cancer Research, vol. 55(23 Suppl.), pp. 55643-5867S (Dec. 1, 1995).
Kranenborg et al. Two-step radio-immunotargeting of renal-cell carcinoma xenografts in nude mice with anti-renal-cell-carcinoma X anti-DTPA bispecific monoclonal antibodies, International Journal of Cancer, vol. 75 (1), pp. 74-80 (Jan. 5, 1998).
Gautherot “Therapy for colon carcinoma xenografts with bispecific antibody—targeted, iodine-131-labeled bivalent hapten,” Cancer, vol. 80, No. Suppl. 12, pp. 2618-2623 (Dec. 15, 1997).
Bosslet et al., “Generation of bispecific monoclonal antibodies for two phase radioimmunotherapy,” British Journal of Cancer, vol. 63/5, pp. 681-686 (1991).
Manetti et al., “Intracellular uptake and catabolism of anti-IgM antibodies and bi-specific antibody-targeted hapten by B-lymphoma cells,” Int. J. Cancer, vol. 63(2), pp. 250-6 (1995).
Barbet et al., “Radioimmunotherapy of LS174T colon carcinoma in nude mice using an iodine-131-labeled bivalent hapten combined with an anti-CEAX anti-indium-DTPA bispecific antibody,” Tumor Biology, vol. 18, No. Suppl. 2, p. 31 (Sep. 1997).
Goodwin et al. “Pre-Targeted Immunoscintigraphy of Murine Tumors with Indium-111-Labeled Bifunctional Haptens,” J. Nucl., Med. vol. 29, pp. 226-234. 1998.
Stickney et al., “Bifunctional Antibody. A Binary Radiopharmaceutical Delivery System for Imaging Colorectal Carcinoma,” Cancer Research, vol. 51, pp. 6650-6655, Dec. 15, 1991.
Gautherot et al. “Therapy for Colon Carcinoma Xenografts with Bispecific Antibody-Targeted, Iodine-131-Labeled Bivalent Hapten.” Cancer Supplement, vol. 80, pp. 2616-2623, 1997.
Barbet et al., “Radioimmunodetection of Medullary Thyroid Carcinoma Using Indium-ill Bivalent Hapten and Anti-CEA X Anti-DTPA-Indium,” The Journal of Nuclear Medicine, vol. 39, No. 7, Jul. 1998.
Schuhmacher et al., “Multistep Tumor Targeting in Nude ice Using Bispecific Antibodies and a Gallium Chelate Suitable for Immunoscintigraphy with Positron Emission Tomography,” Cancer Research, vol. 55, pp. 115-123, Jan. 1, 1995.
Karacay, el al., “Experimental Pretargeting Studies of Cancer with a Humanized anti-CEA x Murine anti-(in-DTPA) Bispecific Antibody Construct and a 99mTc-/188 Re-Labeled Peptide” Bioconjugate Chem. 2000, 11, 842-854 pgs.
Karacay, H., et al. “Pretargeting Studies with a Murine Anti-Colon Specific Antigen-P (CSAp) X Chimeric Anti-[Indium-DPTA] Bispecific Antibody and Technetium-99m-Labeled Peptide,” Cancer Biotherapy and Radiopharmaceuticals, vol. 15, No. 4, 2000, p. 412.
Communication from the European Patent Office, Jul. 10, 2006, supplementary partial European search report for EP 02725484 (6 pages).
Pluckthun et al., “New protein engineering approaches to Multivalent and bispecific antibody fragments,” Immunotechnology 3 (1997) 83-105.
Pack et al., “Tetravalent Miniantibodies with High Avidity Assembling in Escherichia Coli.” J. Mol. Biol. (1995) 246, 28-34.
Sharkey et al., “A Universal Pretargeting System for Cancer Detection and Therapy Using Bispecific Antibody.” Cancer Research 63, 354-363 (Jan. 15, 2003).
Arano, Yasushi, et al., “Reassessment of Diethylenetriaminepentaacetic Acid (

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chimeric, human and humanized anti-CSAp monoclonal antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric, human and humanized anti-CSAp monoclonal antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric, human and humanized anti-CSAp monoclonal antibodies will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4058144

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.