Somatostatin antagonists

Details Somatostatin antagonists Somatostatin antagonists

2003-11-13

2009-06-23

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S001690, C530S311000

Reexamination Certificate

active

07550423

ABSTRACT:
The invention features somatostatin antagonists having a D-amino acid at the second residue.

REFERENCES:
patent: 4395403 (1983-07-01), Bauer et al.
patent: 4435385 (1984-03-01), Bauer et al.
patent: 4650787 (1987-03-01), Schally et al.
patent: 4728638 (1988-03-01), Bauer et al.
patent: 4853371 (1989-08-01), Coy et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 5462926 (1995-10-01), Coy et al.
patent: 5506339 (1996-04-01), Coy et al.
patent: 5597894 (1997-01-01), Coy et al.
patent: 5633263 (1997-05-01), Coy et al.
patent: 5846934 (1998-12-01), Basseet et al.
patent: 5965744 (1999-10-01), Weichert et al.
patent: 6262229 (2001-07-01), Coy et al.
patent: 6703481 (2004-03-01), Coy et al.
patent: 0 029 579 (1980-11-01), None
patent: 0 203 031 (1985-04-01), None
patent: 0 187 622 (1985-12-01), None
patent: 0 214 872 (1987-03-01), None
patent: 0 389 180 (1990-03-01), None
patent: 0 395 417 (1990-10-01), None
patent: 0 215 171 (1990-11-01), None
patent: 0 791 603 (1997-08-01), None
patent: 217635 (2000-03-01), None
patent: 62-61997 (1987-03-01), None
patent: 62-116594 (1987-05-01), None
patent: WO 88/05052 (1988-07-01), None
patent: WO 89/04666 (1989-06-01), None
patent: WO 90/12811 (1990-11-01), None
patent: WO 97/11962 (1997-04-01), None
Bass et al., Molecular Pharmacology, vol. 50, No. 4, (Oct. 1996), pp. 709-715.
Hoyer et al., “Molecular Pharmacology of Somatostatin Receptors”, Naunn-Schmiedeberg's Arch. Pharmaco (1994) 350:441-453.
Raynor et al., “Cloned Somatostatin Receptors: Identification of Subtype-Selective Peptides and Demonstration of High Affinity Binding of Linear Peptides”, Molecular Pharmacology, 43:838-844, (1993).
Lamberts et al., “The Role of Somatostatin and Its Analogs in the Diagnosis and Treatmet of Tumors”. Endocrine Reviews, vol. 12, No. 4. pp. 450-482.
Reisine, et al., “Molecular Biology of Somatostatin Receptors”, Endocrine Reviews, vol. 16., No. 4, pp. 427-442.
Patel et al., “The Somatostatin Receptor Family”, Life Sciences, vol. 57, No. 13, pp. 1249-1265, (1995).
Hofland, et al., “Somatostatin Analogs” Clinical Application in Relation to Human Somatostatin Receptor Subtypes, Biomedical Pharmacology, vol. 50, No. 3, pp. 287-297 (1995).
Reisine, et al., “Molecular Properties of Somatostatin Receptors”, Neuroscience, vol. 67, No. 4, pp. 777-790, (1995).
Bass, et al., “Identification and Characterization of Novel Somatostatin Antagonists”, Molecular Pharmacol 50:709-715 (1996).
Patel et al., “Subtype Selectivity of Peptide Analogs for All Five Cloned Human Somatostatin Receptors”, Endocrinology, vol. 135, No. 6, pp. 2814-2817.
Heiman et al., Neuroendocrinology, 45:429-436 (1987).
Lloyd, et al., Am. J. Physiol., 268:G102-G106 (1995).
Rossowski, W.I., Coy, D.H., Biochemical and Bioophysical Research Comm., 197:366-371 (1993).
Bass et al., Molecular Pharmacology, 50:709-715 (1996).
Osapay, George et al: “Lanthionine-Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies”, J. Med. Chem. (1997), 40(14), 2241-2251 CODEN: JMCMAR; ISSN: 0022-2623, XP002071716.
Melacini, Giuseppe et al: “A Refined Model for the Somatostatin Pharmacophore: Conformational Analysis of Lanthionine-Sandostatin Analogs”, J. Med. Chem. (1997), 40(14), 2252-2258 CODEN: JMCMAR: ISSN: 0022-2623, XP002071717.
Coy, D. H., et al., “Receptor-specific somatostatin analogs: Correlations with biological activity,” Metabolism, 1996, 45(8):21-23.
Fried, J. L., et al., “Somatostatin antagonist analog increases GH, insulin, and glucagons release in the rat,” Peptides, 1982, 3:811-814.
Schally, A. V., et al., “Somatostatin analogs as adjuncts to agonists of luteinizing hormone- releasing hormone in the treatment of experimental prostate cancer,” PNAS, 1987, 84:7275-7279.

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