Method of producing 1,2,4-oxadiazole derivatives

Details Method of producing 1,2,4-oxadiazole derivatives Method of producing 1,2,4-oxadiazole derivatives

2006-04-06

2009-08-18

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07576220

ABSTRACT:
A method for producing a 1,2,4-oxadiazol derivative represented by the formula (1): (1) [wherein, R1represents a methyl group or a phenyl group, and R2represents an optionally substituted linear or branched alkyl group], which comprises reacting a nitrile represented by the formula (2): (2) [wherein, R2represents an optionally substituted linear or branched alkyl group] with acetone or acetophenone in the presence of iron (III) nitrate. The method allows a 1,2,4-oxadiazol derivative exhibiting a useful biological activity to be produced in good yield without the discharge of a harmful waste.

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