Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-29
1995-09-12
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514521, 514523, 514525, 558426, 558430, A61K 31275, C07C25546
Patent
active
054496861
ABSTRACT:
Novel cyclohexanes of Formulas (I) and (II) ##STR1## are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase V.
REFERENCES:
patent: 4795757 (1989-01-01), Regan et al.
Chemical Abstracts, vol. 73, No. 21, Abstract No. 109530f, Nov. 1970.
Chemical Abstracts, vol. 90, No. 11, Abstract No. 90:86895p, Mar. 1979.
Bender Paul E.
Christensen, IV Siegfried B.
Forster Cornelia J.
Haley Jacqueline
Kanagy James M.
Lentz Edward T.
SmithKline Beecham Corporation
Suter Stuart R.
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