Composition and method for the transdermal delivery of bioactive

Details Composition and method for the transdermal delivery of bioactive Composition and method for the transdermal delivery of bioactive

1994-06-23

1995-09-12

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514947, A61K 3816

Patent

active

054496705

ABSTRACT:
A composition for the transdermal delivery of a biologically active peptide having a molecular weight of about 5,000 or less comprising at lest one biologically active peptide, at least one higher alcohol, ester and/or higher amide in combination with at least one pyrrolidone compound of the formula: ##STR1## where R.sub.5 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms, R.sub.6 is hydrogen or a lower alkyl group having 1 to 3 carbon atoms and n is 3, 4 or 5. A method for percutaneously administering such a composition is also disclosed.

REFERENCES:
patent: 3551554 (1970-12-01), Herschler
patent: 4039664 (1977-08-01), Stoughton et al.
patent: 4130667 (1978-12-01), Smith
patent: 4232006 (1980-11-01), Taplin et al.
patent: 4405616 (1983-09-01), Rajadhyaksha
patent: 4650351 (1987-03-01), Engle et al.

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