Drug composition comprising dipeptidyl aldehyde derivative

Details Drug composition comprising dipeptidyl aldehyde derivative Drug composition comprising dipeptidyl aldehyde derivative

2001-09-27

2009-08-11

Pryor, Alton N (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S605000

Reexamination Certificate

active

07572833

ABSTRACT:
The present invention provides a preparation containing a compound of the formula (I)wherein R1is an alkyl group having 1 to 4 carbon atoms or an optionally substituted aryl group having 6 to 10 carbon atoms; R2and R3are the same or different and each is hydrogen or an alkyl group having 1 to 4 carbon atoms, or R2and R3in combination form a ring having 3 to 7 carbon atoms; and R4is a lower alkyl group optionally substituted by aryl, cycloalkyl or aromatic heterocyclic residue, or a pharmaceutically acceptable salt thereof together with a lipid. The preparation shows improved stability and improved absorption and penetration into tissue.

REFERENCES:
patent: 5506243 (1996-04-01), Ando et al.
patent: 5624898 (1997-04-01), Frey, II
patent: 5753296 (1998-05-01), Girsh
patent: 5945121 (1999-08-01), Kato et al.
patent: 6057290 (2000-05-01), Fukiage et al.
patent: 6214800 (2001-04-01), Fukiage et al.
patent: 6342531 (2002-01-01), Azuma et al.
patent: 6423691 (2002-07-01), Azuma et al.
patent: 6551999 (2003-04-01), Fukiage et al.
patent: 0 622 072 (1994-11-01), None
patent: 622 072 (1994-11-01), None
patent: 1 123 919 (2001-08-01), None
patent: 1 221 315 (2002-07-01), None
patent: 58-38219 (1983-03-01), None
patent: 6-329533 (1994-11-01), None
patent: 11-199488 (1999-07-01), None
patent: 2000093093 (2000-04-01), None
patent: 2000290170 (2000-10-01), None
patent: 90/11780 (1990-10-01), None
patent: 96/19211 (1996-06-01), None
patent: WO 97/21690 (1997-06-01), None
patent: 99/44624 (1999-09-01), None
patent: 99/48522 (1999-09-01), None
patent: 01/26648 (2001-04-01), None
patent: 01/41757 (2001-06-01), None
M. Yokota et al., “Calpain Inhibitor Entrapped in Liposome Rescues Ischemic Neuronal Damage”, Brain Research, Feb. 1999, vol. 819, pp. 8-14.
C. Fukiage et al., “SJA6017, A Newly Synthesized Peptide Aldehyde Inhibitor of Calpain: Amelioration of Cataract in Cultured Rat Lenses”, Biochimica et Biophysica Acta, 1997, vol. 1361, pp. 304-312.
Database WPI Week 200148, Derwent Publications Ltd., London, GB; AN 2001-451587, XP002436813 & WO 01/41757 A1 (Senju Pharm Co Ltd) Jun. 14, 2001 *abstract*.

Affiliated with

Also associated with

Rating

Drug composition comprising dipeptidyl aldehyde derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug composition comprising dipeptidyl aldehyde derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug composition comprising dipeptidyl aldehyde derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4052853