Process for the preparation of roflumilast

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07470791

ABSTRACT:
The invention relates to novel processes for the preparation of high-purity roflumilast.

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Cook, D. C., et al., “Process Development Of The PDE IV Inhibitor 3-(Cyclopentyloxy)-N-(3,5-dichloropyrid-4-yl)-4-methoxybenzamide”,Organic Process Research&Development, vol. 2, pp. 157-168, (1998).
Ried, P., “Roflumilast”,Current Opinion In Investigational Drugs, vol. 3, No. 8, pp. 1165-1170, (2002).

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