Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2002-07-12
2008-12-30
Canella, Karen A (Department: 1643)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S016700, C514S017400, C530S300000, C530S329000, C530S330000
Reexamination Certificate
active
07470658
ABSTRACT:
In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit of the adhesion of cells containing particular cell-surface carbohydrates to cells containing cell-surface selectins. Also provided are pharmaceutical compositions comprising invention peptides useful in methods for inhibiting a carbohydrate from binding to a selectin, and in methods of inhibiting tumor cell metastasis in a subject.
REFERENCES:
patent: 4631211 (1986-12-01), Houghten
patent: 5064655 (1991-11-01), Uster et al.
patent: 5200504 (1993-04-01), Ghadiri
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5728802 (1998-03-01), Barrett et al.
patent: WO 98/08949 (1998-03-01), None
patent: WO 98/53071 (1998-11-01), None
Saiki et al (International Journal of Cancer, 1996, vol. 65, pp. 833-839).
Tsukida et al (Journal of Medicinal Chemistry, 1997, vol. 40, pp. 3534-3541).
Rice et al (Science, 1989, vol. 246, pp. 1303-1306).
Shimodaira et al (Cancer Research, 1997, vol. 57, pp. 5201-5206).
Elmore, ‘Peptides and Proteins’, 1968, p. 42.
Aboud-Pirak et al., “Cytotoxic Activity of Daunorubicin or Vindesin Conjugated to A Monoclonal Antibody on Cultured MCF-7 Breast Carcinoma Cells,”Biochem. Pharmacol. 38:641-648 (1989).
Anostario et al., “A Ligand Binding Assay for E-Selectin,”Anal. Biochem. 221:317-322 (1994).
Berg et al., “A Carbohydrate Domain Common to Both Sialyl Leaand Sialyl LexIs Recognized by the Endothelial Cell Leukocyte Adhesion Molecule ELAM-1,”J. Biol. Chem. 266:14869-14872 (1991).
Bevilacqua et al., “Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins,”Science243:1160-1165 (1989).
Bodansky M.,Principles of Peptide Synthesis2nd ed. (Springer-Verlag) 1988 and (1993 Supp.).
Briand et al., “Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies,”J. Immunol. Meth. 156:255-265 (1992).
Dillman et al., “Significance of antigen, drug, and tumor cell targets in the preclinical evaluation of doxorubicin, methotrexate, and mitomycin-C monoclonal antibody immunoconjugates,”Mol. Biother. 1:250-255 (1989).
Dyson et al., “The Physical Basis for Induction of Protein-Reactive Antipeptide Antibodies,”Ann. Rev. of Biophysics and Biophysical Chem. 17:305-324 (1988).
Everiss et al., “The Vibrio cholerae acfB colonization determinant encodes an inner membrane protein that is related to a family of signal-transducing proteins,”Infect. Immun., 62:3289-3298 (1994).
Fitzpatrick and Garnett, “Studies on the mechanism of action of an MTX-HSA-MoAb conjugate,”Anti-Cancer Drug Des. 10:11-24 (1995).
Fitzpatrick and Garnett, “Design, synthesis andin vitrotesting of methotrexate carrier conjugates linked via oligopeptide spacers,”Anti-Cancer Drug Des. 10:1-9 (1995).
Goldman et al., “Targeted gene delivery to Kaposi's sarcoma cellsviathe fibroblast growth factor receptor1,”Cancer Res. 15:1447-1451 (1997).
Heerze et al., “Utilization of sialic acid-binding synthetic peptide sequences derived from pertussis toxin as novel anti-inflammatory agents,”Glycobiology5(4):427-433 (1995).
Henn et al., “Synthesis of 2′-Deoxyuridine and 5-Fluoro-2′-deoxyuridine Derivatives and Evaluation in Antibody Targeting studies,”J. Med. Chem. 36:1570-1579 (1993).
Irimura et al., “Colorectal cancer metastasis determined by carbohydrate-mediated cell adhesion: role of sialyl-Lexantigens,”Cancer Biol. 4:319-324 (1993).
Johnston et al., “Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation,”Cell56:1033-1044 (1989).
Kannagi R., “Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer ,”Glycoconjugate J.4:577-584 (1997).
Krauer et al., “Antitumor Effect of 2′-Deoxy-5-fluorouridine Conjugates against a Murine Thymoma and Colon Carcinoma Xenografts,”Cancer Res.52:132-137 (1992).
Kukowska-Latallo et al., “A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group α(1,3/1,4) fucosyltransferase,”Genes&Develop.4:1288-1303 (1990).
Laskey et al., “Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain,”Cell56:1045-1055 (1989).
Martens et al., “Peptides which bind to E-selectin and block neutrophil adhesion,”J. Biol. Chem.270(36):21129-21136 (1995).
Martín-Satué et al., “Enhanced Expression of α(1,3)-Fucosyltransferase Genes Correlates with E-selectin-mediated Adhesion and metastatic Potential of Human Lung Adenocarcinoma Cells1, ”Cancer Res.58:1544-1550 (1998).
McEver R.P., “Selectin-carbohydrate interactions durning inflammation and metastasis,”Glycoconjugate J.4:585-591 (1997).
Miyasaka M., “Cancer Metastasis and Adhesion Molecules,”Clin. Orthop.312:10-18 (1995).
Morikawa et al., “Treatment of focal cerebral ischemia with synthetic oligopeptide corresponding to lectin domain of selectin,”Stroke27(5):951-955 (1996).
Murakami et al., “Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae,”Nature Genetics, 10:261-268 (1995).
Nakamori et al., “Increased Expression of Sialyl LewisxAntigen Correlates with Poor Survival in Patients with Colorectal Carcinoma: Clinicopathological and Immunohistochemical Study1,”Cancer Res.53:3632-3637 (1993).
Nakashio et al., “The Association of Metastasis with the Expression of Adhesion Molecules in Cell Lines Derived from Human Gastric Cancer,”Anticancer Res.17:293-300 (1997).
Nelson et al., “Higher-Affinity Oligosaccharide Ligands for E-Selectin,”J. Clin. Invest.91:1157-1166 (1993).
Pelton et al., “Conformationally restricted analogs of somatostatin with high μ-opiate receptor specificity,” Proc. Natl. Acad. Sci. USA 81:236-239 (1985).
Rees et al., Protein Engineering: A Practical Approach IRL Press 1992.
Rowland et al., “Preclinical investigation of the antitumour effects of anti-CD19-idarubicin immunoconjugates,”Cancer Immunol. Immunother. 37:195-202 (1993).
Rozdzinski et al., “Prokaryotic peptides that block leukocyte adherence to selectins,”J. Exp. Med. 178:917-924 (1993).
Sato et al., “The Association of Sialyl Lewis Antigen with the Metastatic Potential of Human Colon Cancer Cells,”Anticancer Res. 17:3505-3512 (1997).
Sawada et al., “Differential E-selectin-dependent Adhesion Efficiency in Sublines of a Human Colon Cancer Exhibiting Distinct Metastatic Potentials,”J. Biol. Chem. 269:1425-1431 (1994).
Schechter et al., “Indirect Immunotargeting of CIS-PT To Human Epidermoid Carcinoma KB Using the Avidin-Biotin System,”Int. J. Cancer48:167-172 (1991).
Schott et al., “Comparison of Linear and Branched Peptide Forms (MAPs) in the Induction of T Helper Responses to Point-Mutated ras Immunogens,”Cell Immun. 174:199-209 (1996).
Shawler et al., “Preclinical Trials Using an Immunoconjugate of T101 and Methotrexate in an Athymic Mouse/Human T-Cell Tumor Model,”J. Biol. Resp. Mod. 7:608-618 (1988).
Shih et al., “Internalization of an intact doxorubicin immunoconjugate,”Cancer Immunol. Immunother. 38:92-98 (1994).
Sivam et al., “Therapeutic Efficacy of a Doxorubicin Immunoconjugate in a Preclinical Model of Spontaneous Metastatic Human Meloanomal,” Cancer Res. 55:2352-2356 (1995).
Smith et al., “Building Synthetic Antibodies as Adhesive Ligands for Integrins,” J. Biol. Chem. 269:32788-32795 (1994).
Smy
Fukuda Michiko
Fukuda Minoru
Burnham Institute for Medical Research
Canella Karen A
McDermott Will & Emery LLP
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