Preparation of intermediates for acetycholinesterase inhibitors

Details Preparation of intermediates for acetycholinesterase inhibitors Preparation of intermediates for acetycholinesterase inhibitors

2003-07-01

2008-11-04

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07446203

ABSTRACT:
A simple, industrial process for the preparation of the intermediates of acetyl cholinesterase inhibitors is provided. Thus, for example, 5,6-dimethoxy-2-(4-pyridyl)methyl-1-indanone is hydrogenated using platinum oxide catalyst in the presence of hydrochloric acid under a pressure of 2 bars to give 4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, which is then converted to donepezil hydrochloride, an acetyl cholinesterase inhibitor.

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PCT International Search Report Dated Jul. 1, 2003.
J. Heterocyclic Chem. 2(4), 366-370 (1965).

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